Blood Smear

Front 1

Look @ Koss Atlas

Back 1

MARKED ANISOCYTOSIS - POIKILOCYTOSIS
 Severe iron deficiency anemia
 Severe megaloblastic anemia
 Microangiopathic hemolysis
 Leukoerythroblastosis
 Hemoglobinopathies

Front 2

1. macroovalocytes + hypersegmented neutrophils think what condition?
2. Bite cells & Heinz bodies?

Schistocyte lacks central pallor

Back 2

1. B12 deficiency
2. G6PD

Front 3

SPHEROCYTES -- Hereditary spherocytosis & Autoimmune hemolysis & Severe burns

Back 3

ELLIPTOCYTES / OVALOCYTE:
Hereditary elliptocytosis, Megaloblastic anemia, Severe iron deficiency anemia, Thalassemia, Congenital, dyserythropoietic anemia, Sickle cell anemia

Front 4

TARGET CELLS: Hemoglobinopathies, Thalassemia, Liver disease, Iron deficiency anemia, Post splenectomy, Artifact of preparation

Back 4

SCHISTOCYTES - **MICROANGIOPATHIC HEMOLYSIS**, Thrombotic Thrombocytopenic Purpura, TTP / HUS, Disseminated Intravascular Coagulation DIC, Malignant hypertension, Eclampsia, Sepsis / Prosthetic heart valve / Other

Front 5

1. Why does a target cell look the way it does?

Schistocyte synonyms: schistocytes, helmet cell, triangulocyte, keratocyte, horn cell, fragmented RBCs

Back 5

1. B/c it has a larger membrane & hemoglobin can accumulate in the middle of the central pallor

Front 6

TEAR DROP CELLS: Leukoerythroblastosis, meylofibrosis, Megaloblastic anemias, Thalassemias, Artifact of slide preparation

Associated w/ things that change the bone marrow. If it is an artifact, the tails will all be facing the same direction

Back 6

STOMATOCYTE: Hereditary stomatocytosis, Rh null disease, Alcoholism, Liver disease, Artifact

Not much pathology associated w/ this, Central pallor is slit like

Front 7

SPICULATED RED CELLS AKA BURR or ACANTHOCYTES or CRENATED
Caused by: Artifact, Liver Disease, Renal Disease, Hemolysis, Abeta-lipoproteinemia, others
Acanthocytes are due to lipoproteinemia

Back 7

Burr cells due to renal failure or solution sits for a while

BASOPHILIC STIPPLING: Acute blood loss, Lead toxicity, Megaloblastic anemias, Thalassemias, Refractory anemia / Myelodysplasia, Congenital dyserythropoietic anemia, Pyrimidine – 5’ nucleotidase deficiency,

Front 8

1. If Sickle cells are observed, what level of SCD can be thrown out?
2. A linear arrangement of at least 4 RBCs, like a stack of coins
3. What can happen to RBC count and MCV in Rouleaux or RBC agglutination?

Back 8

1. Trait
2. Rouleaux
3. RBC artificially low and MCV is high

Front 9

ROULEAUX - Multiple Myeloma and Monoclonal
Gammopathies, Hepergammaglobulinemia, Chronic infections, Chronic inflammatory conditions, Lymphoprolipherative Disorders, Artifact

Back 9

RBC AGGLUTINATION: Cold autoimmune hemolytic anemia, Paroxysmal cold hemoglobinuria, Cold agglutinin syndrome, Malignant lymphoma associated / lg M, Plasma cell dyscrasia associated / lg M

Front 10

1. What is the main benefit of using supravital stain over Romanovsky's/Wright Giemsa stain?
2. Type of stain that Howell-Jolly stain shows up on?

Back 10

1. Visual Heinz bodies - HGB
2. Wright Giemsa

Front 11

PAPPENHEIMER BODIES: Splenectomy, Sideroblastic anemias, Megaloblastic anemias, Thalassemias, Hemolytic anemias, Congenital dyserythropoietic anemias
-- in chronic situations due to iron metabolism problems, found in periphery of the cell, 1-2 small blue-purple-green granules

Back 11

HOWELL JOLLY BODIES: Post splenectomy, Asplenia syndrome, Splenic atrophy, Hemolytic anemias, Megaloblastic anemias, Dyserythropoiesis
--- Just off the central pallor

Front 12

HEINZ BODIES: Unstable hemoglobins, G-6-PD deficiency, Post splenectomy

Back 12

...