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10 Cards in this Set
- Front
- Back
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4 steps of hemostasis
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(1) vasoconstriction
(2) platelet plug (3) fibrin mesh (thrombus formation) (4) dissolution of clot by plasmin |
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most important control of hemostasis
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concentration of active thrombin
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2 modes of thrombin regulation
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(1) regulation of prothrombin to thrombin conversion
(2) inactivation of thrombin by anti-thrombin III |
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2 Vitamin K antagonists
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Dicoumaral, Warfarin
(structural analogs of vit. K) |
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Role of Vitamin K in hemostasis
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required for synthesis of activatable prothrombin
-facilitates gamma-carboxylation of Glu residues near prothrombin NH2 terminal |
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Describe the role of Ca2+ in hemostasis
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gamma-carboxyglutamate (Gla) of prothrombin binds Ca2+. Ca2+-binding anchors prothrombin to phospholipid membranes, bringing it close to its activiting factors, Xa and Va
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Serpins
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Serine Protease Inhibitors, e.g.: Anti-thrombin III
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HEPARIN
-structure -function regarding hemostasis |
glycosaminoglucan
binds anti-thrombin III and enhances its activity |
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2 key roles of thrombin
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platelet activation - makes them sticky
conversion of fibrinogen to fibrin--> mesh |
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6 enzymes that function to maintain reduced atomsphere in RBCs
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MetHb reductase
superoxide dismutase glutathione peroxidase glutathione reductase G6PD DPG mutase |
