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249 Cards in this Set
- Front
- Back
Formed Elements (Cells) |
Red Blood Cells (RBC) White Blood Cells (WBC/ Leukocytes) Thrombocytes (Platelets) |
|
Blood is made up of? |
55% Plasma, 1%> Leukocytes and Platelets, 45% Erythrocytes |
|
Mean Temp. of Blood |
100.4 F |
|
Osmolarity of Blood |
300 mOsm/L (most from Na+), 286 mOsm/L outside of the cell |
|
Normal pH level |
7.4 - This is the concentration of positively charged hydrogen ions, will cause proteins to denature |
|
Hemoglobin (Weight of RBC) |
RBC weigh more than glucose due to the iron being heavy |
|
Hematocrit (packed cell volume) |
Normal: 45%. Higher in men due to larger muscle mass which requires more energy and needs more carbohydrates and oxygen. This is the percentage of the volume of all formed elements (erythrocytes, leukocytes, and platelets) in the blood. |
|
Mean Salinity |
0.9% mainly NaCl |
|
Blood Transports: |
Wastes (primarily nitrogenous wastes) Gasses Nutrients Hormones
|
|
Blood Regulates: |
Body Temperature pH (Buffers) Volume (osmotic pressure of salts and proteins)- change by moving in Na+ |
|
Blood Protects: |
Blood loss (clotting factors) Infections (WBC's, Antibodies, Complement) |
|
Plasma protein Albumins function is? |
Responsible for Colloid (Oncotic pressure) osmotic pressure. blood viscosity, transport lipids, hormones, calcium, and other solutes; buffer blood pH |
|
Plasma protein Prothrombins function is? |
Promotes blood clotting, made in liver. |
|
Plasma protein Fibrinogens function is? |
becomes fibrin, major component of blood clots. |
|
Hemopoiesis |
The making of blood cells, normally in bone marrow Hemo- Blood Poiesis- Manufacture of |
|
How does Hemopoiesis begin? |
Begins with "stem cells" (pluripotential/hemocytoblast) that continually reproduce themselves Childhood: in bones, liver, spleen and kidney Adulthood: axial bones (especially pelvis and sternum) and long bones- proximal epiphysis
|
|
Homeopoiesis stem cells commit to form? |
Reticular cells Mast cells Adipocytes Myeloid Stem Cells Lymphoid Stem Cells |
|
Reticular Cells |
Fibers in lymph system and marrow, found in connective tissue, tonsils, lymphnodes |
|
Mast Cells |
Histamine release in connective tissue, in areolar connective tissue, under all epithelium |
|
Myeloid Stem Cells are |
Erythrocytes Granulocytes- WBC Monocytes Megakaryocytes- Big nucleotic cells- that come off in pieces as platelets |
|
Myeloid stem cells complete maturation in? |
Bone marrow |
|
Myeloid stem cells form these types of cells |
Colony-forming unit -CFU-E (erythorcyte) -CFU-Meg (megakaryocyte) -CFU-Gm (granulocytes) |
|
Erythropoetin |
Hormone that says I need more erythrocytes |
|
Myeloid stem cells are stimulated to produce the final cell by ? |
Hormones -Macrophages- primary stimulus for granulocytes & monocytes -Kidney -Liver- primary stimulus for megakaryocyte b/c everything goes through the liver -Endothelial Cells
|
|
Lymphoid stem cells complete maturation in ? |
The lymph system |
|
Lymphoid stem cells form these types of cells |
1. T Lymphocyte- cell to cell fighter 2. B Lymphocyte- Becomes plasma cell and makes antibodies 3. Natural Killer Cell- non-specific defense |
|
Lymphoid stem cells are stimulated to produce the final cell by |
Interleukins released from other lymphocytes |
|
MHC (Major histocompatibility complex) |
This cell is my cell |
|
Antibodies |
Made to fight anything foreign in the body |
|
Antigens |
A toxin or foreign substance that induces an immune response in the body, especially the release of antibodies |
|
Only place stuff can get in/out of the blood stream is a ? |
Capillary, which is smaller in diameter than RBC's causing them to change shape and bend to fit |
|
Agglutination |
Everything stuck together |
|
Erythropoiesis |
RBC Formation
|
|
Erythrocytes 1. Contents 2. Shape 3. Structure 4. Respiration 5. Function |
1. Hemoglobin 2. Donut 3. Spectrin and Agglutinogens 4. Anaerobic (glucose becomes lactic acid) 5. Gas transport(O2 primarily), oncotic pressure, nitric oxide transport |
|
Oncotic Pressure |
Movement of H2O to higher concentration of red blood cells |
|
Hemoglobin (Hb) 1.Composition 2. Gas Transport |
1. 4 globin chains, 1 heme group per chain, 1 iron molecule per heme, 1 oxygen per iron (no O2 attachment if there is no iron) 2. Oxyhemoglobin, deoxyhemoglobin, carbaminohemoglobin - 300 million/cell |
|
Necessary Nutrients for Erythropoiesis |
1. Vitmain B12 (intrinsic factor) -need to manufacture RBC but is so large that when you eat it you can't get it out of your digestive tract w/o assistance of additional protein 2. Iron (protein carriers) -iron has to attach to a protein carrier or it will mess up other reactions in the body, a deficiency in iron will give you anemia |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Monocytes role in the immune system is?
|
Antigen presenting cells
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Monocytes role in the immune system is?
|
Antigen presenting cells
|
|
_____ are the first to fight off invasion
|
Neutrophils
|
|
Erythrocytes live for how many days?
|
120
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Monocytes role in the immune system is?
|
Antigen presenting cells
|
|
_____ are the first to fight off invasion
|
Neutrophils
|
|
Erythrocytes live for how many days?
|
120
|
|
Neutrophils contain defensins because?
|
They are proteins used to kill bacteria on contact
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Monocytes role in the immune system is?
|
Antigen presenting cells
|
|
_____ are the first to fight off invasion
|
Neutrophils
|
|
Erythrocytes live for how many days?
|
120
|
|
Neutrophils contain defensins because?
|
They are proteins used to kill bacteria on contact
|
|
Neutrophils contain lysozymes because?
|
They are enzymes that destroy certain bacteria, and speed up reactions
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |
|
Hemocytoblast to Erthryocyte takes?
|
5 days
|
|
Thalassemia
|
One globin chain is absent or faulty, 3 functional globin chains
|
|
Sickle Cell Anemia
|
One globin chain is faulty and under low O2 conditions, chains clump together and get stiff
|
|
Sickle Cell Trait
|
Recessive gene, so can carry the trait
Prevents malaria |
|
Polycythemia
|
Too many red blood cells
Primarily from cancer Secondary from dehydration and excess erythropoetin It is a problem because of viscosity, the heart has to workharder |
|
Leukopoiesis
|
White blood cell formation
|
|
Role of Monocytes in the blood stream
|
Patrol the body for invaders
Role in the immune system |
|
Monocytes are stationed in______ cells inside theses organs?
|
stationed in dendritic cells inside the lungs, liver, spleen, and skin
|
|
Monocytes become _____ to eat invaders and garbage
|
Macrophages (Big-eaters)
|
|
Monocytes role in the immune system is?
|
Antigen presenting cells
|
|
_____ are the first to fight off invasion
|
Neutrophils
|
|
Erythrocytes live for how many days?
|
120
|
|
Neutrophils contain defensins because?
|
They are proteins used to kill bacteria on contact
|
|
Neutrophils contain lysozymes because?
|
They are enzymes that destroy certain bacteria, and speed up reactions
|
|
Where is Erythropoietin produced?
|
in the Kidney and the Liver
|
|
Erythropoietin are stimulated by?
|
Blood loss, poor hemoglobin, decreased O2, testosterone
|
|
Hemorrhagic anemia
|
blood loss
|
|
Hemolytic anemia
|
blood cell lyses- infection, the cells exploded
|
|
Aplastic anemia
|
Normal cells not found, w/o shape anemia, affects RBC and WBC
|
|
Iron deficiency anemia
|
lack of iron
|
|
Pernicious anemia
|
lack of vitamin B12, usually lack of intrinsic factor, deadly
|
|
Three types of abnormal hemoglobin are?
|
Thalassemia
Sickle Cell Anemia Sickle Cell Trait |