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37 Cards in this Set

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NOTE: THESE ARE ALL BIOLOGICAL RESPONSE MODIFIERS
:O)
This blocks the ATP-binding site of c-abl making it effective treatment for Ph+ CML (9:22)
Imatinib mesylate (Gleevac)
*mentioned in review
What else does imatinib mesylate inhibit?
c-kit and PDGF associated tyrosine kinases
Use and SE of imatinib mesylate
GI stromal tumors and CML

Thrombocytopenia and Neutropenia
These inhibits EGF-receptor associated tyrosine kinases
Erlotinib
Gefitinib

*mentioned in review
Trastuzumab (Herceptin) Use and MOA
Used for p185-her2 (=) breast cancer

Induces antibody-dependent cell mediated cytotoxicity
SE of Trastuzumab
Cardiotoxicity
*esp. when combined w/anthracyclines
Cetuximab
Chimeric monoclonal Ab directed against the EGF receptor
Humanized monoclonal Ab directed against the VEGF receptor. What does it do?
Bevacizumab
(-) angiogenesis

*mentioned in review
Use of Bevacizumab? Risks?
Metastatic colon cancer

Incerase risk of TE (thromboemolism)
Rituximab and MOA
Recombinant chimeric (mouse/human) anti-CD20 monoclonal Ab

Promotes complement mediated lysis of malignant B cells in non Hodgkin's lymphoma

*mentioned in review
One more time, what Rituximab used for?
Non-Hodgkin's lymphoma
Rituximab side effects
Can result in HBV reactivation
Mouse monoclonal anti-CD20 that can be linked to yttrium-90 or indium 111
Ibritumomab tiuxetan(Zevalin)
How does Zevalin work?
Targets radioactivity to CD-20 expressing B cells
Tositumomab can be linked to ?
Mouse monoclonal anti-CD20 Ab that can be linked to I-131
Gemtuzmab ozogamicin
Recombinant monoclonal Ab directed against myeloid cell surface antigen 33
What DNA cleaving Ab is conjugated w/gemtuzmab ozogamycin
Calichaemicin
Levamisole fxn
Stimulates T cell activity
IL-2 (Aldesleukin) fxn
Activation of LAK (lymphokine-activated killer)cells
Interferon alpha used for ...
Multiple myeloma
Kaposi's sarcoma
Thalidomide used for
Multiple myeloma
All-trans-retinoic acid used for
First line therapy for promyelocytic leukemia
Arsenic trioxide use
Second line therapy for actue promyelocytic leukemia
Toxicities of arsenic trioxide
Retinoic acid syndrome in acute promyelocytic leukemia

Cardiac arrythmias
Bexarotene
Selective retinoid X receptor agonist
Use of Bexarotene
Cutaneous T cell lymphoma
Denileukin difitox structure
Recombinant chimeric protein containing the receptor binding portion of IL-2 fused to A and B subunits of Diptheria toxin
Samarium SM 153 lexidronam structure
Radionucleotide chelated to ethylenediamine tetramethylene
Use of Samarium SM 153 lexidronam
Preferentially distributes to bone- used for metstatic bone lesions
Humanized anti-CD25 monoclonal Ab and its use?
Alemtuzumab ( uh-lem-TOOZ-uh-mab)

Use for CLL
Bortezomib (bore TEH zo mib)and use
Proteosome inhibitor

Multiple Myeloma
Celecoxib
Inhibits COX-2

Prevention of colon cancer in pts. w/ familial adenomatous polyposis
Bisphosphonates (Etidronate, Pamidronate, Zoledronate) uses
1. Hypercalcemia
2. Osteolytic bone lesions in MM
3. Metastatic breast cancer
4. Bone metastases from solid tumors
5. Prevention of bone loss in men taking leuprolide
Suppossed MOA of the bisphosphonates
(-) of osteoclasts and induction of osteoclast apoptosis
bacillus Calmette-Guerin use? Used with what?
Bladder cancer

Epirubicin
Palifermin and use
Recombinant version of human kertinocyte growth factor

Treats chemotherapy induced mucositis (good thing)