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22 Cards in this Set
- Front
- Back
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What are four classes of ADs?
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tricyclic (TCA)
serotonin selective re-uptake inhibitors (SSRI) monoamine oxidase inhibitor (MAOI) misc (atypical, heterocyclic, 2nd or 3rd generation, "other") |
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How do TCAs work
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block reuptake of NE and/or 5HT --> inc synaptic levels
AND block receptors |
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Which TCAs favor 5HT reuptake block?
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tertiary amines, but becuase they are metabolized to secondary amines, they also block NE
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Which TCAs favor NE reuptake block?
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secondary amines
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How do SSRIs work?
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block reuptake of 5HT, don't block receptors
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How does sertraline differ?
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also causes some block of DA reuptake
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How does venlafaxine differ
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also inhibits NE reuptake (SNRI) (more like SSRIs than TCAs because it doesn't block receptors)
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How do MAOIs work?
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block oxidative metabolism of amines by IRREVERSIBLY inhibiting MAO-A and MAO-B
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How do trazodone and nefazodone work?
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1. weak inhibition of 5HT reuptake, some NE reuptake
2. block certain postsynaptic 5HT receptors 3. block presynaptic 5HT receptors |
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How does mirtazapine work?
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blocks alpha-2 and 5HT presynaptic receptors --> increases noradrenergic and serotonergic transmission
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How does bupropion work?
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blocks DA reuptake, also NE and 5HT
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Describe acute TCA effects
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drowsy, dysphoric, anxious, impaired cognition, autonomic effects
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Describe chronic TCA effects
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2-6 wks- most or all depression sx improved, side effects diminish
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is mood elevation euphoria?
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no
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Describe acute SSRI effects
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CNS stimulation, anxiety, agitation (excess serotonin)
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Describe chronic SSRI effects
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2-6 wks- most or all sx of depression improved
CNS activation remains, but anxiety resolves |
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Describe acute MAOI effects
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CNS stimulation, agitation, possibly euphoria
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Describe chronic MAOI effects
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2-6 wks- most or all sx of depression improved
CNS activation remains, may be lessened |
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Other indications for TCAs
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panic disorder
OCD (clomipramine only) anxiety ds, enuresis chronic pain |
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other indications for SSRIs
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panic disorder
OCD eating disorder ADD |
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Other indications for MAOIs
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panic disorder
agoraphobia |
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Other indications for bupropion
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(Zyban)
nicotine addiction/withdrawal |
