Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
accumulation factor
peak conc |
= 1/fraction lost in one dose interval
--> peak conc = peak conc after 1st dose x accumulation factor |
|
|
hepatic clearance
|
= Q x (Ci-Co)/(Co)
= Q x ER |
|
|
systemic bioavailability
|
= extent of absorption x (1 - ER)
|
|
|
t1/2
|
=.693/k
|
|
|
Vd
|
=Xo/Co
|
|
|
CL
|
=k x Vd
|
|
|
Dosing rate
|
= CL x Css
|
|
|
Maintenance dose
|
=dosing rate x dosing interval
|
|
|
loading dose
|
= Vd x Target conc
|
|
|
Css
|
= dosing rate / CL
|
|
|
TI
|
= LD50 / ED50
OR = TD50 / ED50 |
|
|
what shifts the curve to the right
|
presence of competitive antagonist
|
|
|
what decreases the maximum effect
|
presence of non-competitive antagonist
|
