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13 Cards in this Set

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accumulation factor

peak conc
= 1/fraction lost in one dose interval

--> peak conc = peak conc after 1st dose x accumulation factor
hepatic clearance
= Q x (Ci-Co)/(Co)
= Q x ER
systemic bioavailability
= extent of absorption x (1 - ER)
t1/2
=.693/k
Vd
=Xo/Co
CL
=k x Vd
Dosing rate
= CL x Css
Maintenance dose
=dosing rate x dosing interval
loading dose
= Vd x Target conc
Css
= dosing rate / CL
TI
= LD50 / ED50
OR
= TD50 / ED50
what shifts the curve to the right
presence of competitive antagonist
what decreases the maximum effect
presence of non-competitive antagonist