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33 Cards in this Set

  • Front
  • Back
MCC of genetic variation in drug resposne
SNPs
codeine
cyp2d6
beta blockers
cyp2d6
tricyclic antidepressants
cyp2d6
dextromethorphan
cyp2d6
cyp2d6 slow metabolizers
caucasians
cyp2d6 fast metabolizers
east africans
cyp2c19
Asians
citalopram
cyp2c19
diazepam
cyp2c19
mephenytoin
cyp2c19
phenytoin
cyp2c19 and cyp2c9
proguanil
cyp2c19
omeprazole
cyp2c19
warfarin
cyp2c9
cyp2c9 slow metabolizers
3% caucasian
5-FU
dihydropyrimidine dehydrogenase
(1%)
prolonged action of succinylcholine
Asp70Gly mutation of psuedocholinesterase
isoniazid (INH)
NAT-2
procainamide
NAT-2
sulfonamide
NAT-2
histamine
NAT-2
caffeine
NAT-2
dapsone
NAT-2
hydralazine
NAT-2
NAT-2 slow acetylators
1/2 caucasians
1/2 Africans
1/5 Egyptians
~16% Asians
thiopurines
TPMT
6-mercaptopurine (6-MP)
TPMT
azathioprine
TPMT
levodopa
COMT
anti-retroviral drugs
MDR-1 (ABCB1)
fexofenadine
MDR-1 (ABCB1)
isoproterenol
B2 adrenergic receptor function
(ADRB2)