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33 Cards in this Set
- Front
- Back
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MCC of genetic variation in drug resposne
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SNPs
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codeine
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cyp2d6
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beta blockers
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cyp2d6
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tricyclic antidepressants
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cyp2d6
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dextromethorphan
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cyp2d6
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cyp2d6 slow metabolizers
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caucasians
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cyp2d6 fast metabolizers
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east africans
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cyp2c19
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Asians
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citalopram
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cyp2c19
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diazepam
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cyp2c19
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mephenytoin
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cyp2c19
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phenytoin
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cyp2c19 and cyp2c9
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proguanil
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cyp2c19
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omeprazole
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cyp2c19
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warfarin
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cyp2c9
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cyp2c9 slow metabolizers
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3% caucasian
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5-FU
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dihydropyrimidine dehydrogenase
(1%) |
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prolonged action of succinylcholine
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Asp70Gly mutation of psuedocholinesterase
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isoniazid (INH)
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NAT-2
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procainamide
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NAT-2
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sulfonamide
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NAT-2
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histamine
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NAT-2
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caffeine
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NAT-2
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dapsone
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NAT-2
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hydralazine
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NAT-2
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NAT-2 slow acetylators
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1/2 caucasians
1/2 Africans 1/5 Egyptians ~16% Asians |
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thiopurines
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TPMT
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6-mercaptopurine (6-MP)
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TPMT
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azathioprine
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TPMT
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levodopa
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COMT
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anti-retroviral drugs
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MDR-1 (ABCB1)
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fexofenadine
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MDR-1 (ABCB1)
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isoproterenol
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B2 adrenergic receptor function
(ADRB2) |
