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17 Cards in this Set
- Front
- Back
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Initial treatment for mania
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was lithium
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Other effective agents
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anticonvulsants, carbamazepine, and valproic
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In Bipolar II
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antidepressants may be safe and effective, although lithium still the first choice
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First-line agents in bipolar disorder
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lithium and divalproex
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Narrow therapeutic window
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the therapeutic dose is very close to the toxic dose
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Lithium demonstrates
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a narrow therapeutic window
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Lithium is prescribed
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by dose, stage of symptoms and by concentration in the blood
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One critical indicator of lithium toxicity
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gastrointestinal symptoms
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Warning signs that require a lithium blood level
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are worsening of tremor, confusion stupor, and slurred speech
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A sign of buildup of lithium
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is an alteration in normal kidney functioning
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When is important to take a lithium level?
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during imitation, with dosage changes, with breakthrough symptoms and any time toxicity is suspected
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Lithium mechanism of action
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are unclear but effects on DA and NE may be linked to lithium's benefit in mania
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Three types of anticonvulsants effectives for bipolar
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Carbamazepine (Tegretol), divalproex (Depatoke), and Lamotrigine (Lamictal)
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Carbamazepine overdose
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produces neurologic and cardiac malfunctions
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Divalproex overdose
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may produce somnolence and coma
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Lamotrigine overdose
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is associated with rare, serious, and potentially life-threating dermatologic reactions
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SGA
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have become established as primary agents of acute mania and mixed mania
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