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6 Cards in this Set

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Pyruvate Dehydrogenase complex E1- name its major reactants, products, cofactors and regulators
Reactant: pyruvate
Product: 2C pyruvate fragment
Cofactor: thiamine pyrophosphate (prosthetic)
Regulation: Phosphorylation (deactivated by PDH kinase/activated by PDH phophotase) Allosterically by: acetyl CoA and NADH
Pyruvate Dehydrogenase complex E2- name its major reactants, products, cofactors and regulators
R: 2C pyruvate fragment
P: acetyl CoA
C: CoA (co-substrate) from pantothenic acid / Lipoamide (prosthetic)
Reg: feedback inhibition by acetyl CoA product
Pyruvate Dehydrogenase complex E3- name its major reactants, products, cofactors and regulators
R: lipoate, FADH2, NAD+
P:oxidized lipoate on E2 and NADH
C: FAD (prosthetic) from riboflavin / NAD+ (co-substrate) from niacin
Reg:
Citric acid Cycle enzymes that produce NADH
Isocitrate Dehydrogenase
a-Ketoglutarate Dehydrogenase
Malate Dehydrogenase
Citric acid cycle enzyme that produces FADH2
Succinate Dehydrogenase
Citric acid cycle enzyme that Produces GTP
Succinyl CoA synthetase