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10 Cards in this Set

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  • Back
What is the normal concentration of albumin in the serum?
4g/dL
Name 4 F(x)'s of Albumin?
translocate bilirubin, fatty acids, and other compounds bound non-specifically. Also penicillin, aspiring, sulfa-drugs, and steroid hormones
Where is albumin synthesized?
Liver`
What class of plasma proteins is not synthesized in the liver?
Gamma Globulins
What is the most abundant plasma protein?
Albumin
Which PP binds iron?
Alpha-2 globulins and beta globulin fraction involved in iron homeostasis

TRANSFERRIN
Which PP binds vitamin A derivatives?
Alpha-1 globulin which contains retinol binding protein
What happens to the free hemoglobin the serum?
Fe2+, ferous iron, is usually lost through the kidneys, unless haptoglobulin binds to it.
Name a blue protein and it's Fx
Ceruloplasmin: copper-containing protein w/ Cu ions in 1+ and 2+ states used to oxidize any free Fe2+ to Fe3+ in the serum
what is the most abundant alpha-1 globulin? fx? clinical result of it's absence or malfunction?
Alpha-1 antiprotease (AKA antitrypsin) 90%.
inhibits elastase, an enzyme that breaks down connective tissue elastin
PTs homozygeous for defect in elastin are at high risk for emphysema.