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14 Cards in this Set

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Disorders of absorption of long chain fatty acids in early digestive stage due to impaired lipolysis(problems with pancreatic lipase):
Chronic pancreatitis
Cystic fibrosis
Gastrinoma (pH <7.0)
Disorders of absorption of long chain fatty acids in late digestive stage due to errors in conjugation bile acids leading to impaired micelle formation
Defects in enterohepatic circulation of bile acids
Disorders of absorption of long chain fatty acids in late digestive stage due to errors in conjugation bile acids leading to impaired movement of micelles
Thick water layer as in bacterial overgrowth syndromes
Disorders of absorption of long chain fatty acids in absorptive stage due to errors of esterification of fatty acids leading to Impaired mucosal uptake & re-esterification
Mucosal inflammation as in celiac sprue

Intestinal resection
Disorders of absorption of long chain fatty acids in postabsorptive stage due to errors in chylomicron formation
Autosomal recessive abetalipoproteinemia which causes acanthocytosis (abnormal erythrocytes due to bad membrane phospholipid content)
Disorders of absorption of long chain fatty acids in postabsorptive stage due to Impaired delivery from intestine via lymphatics
Abnormal lymphatics as in intestinal lymphangiectasia
Clinical manifestations of:
steatorrhea: increase in stool fat excretion to > 6% of dietary fat intake.
weight loss.
Diarrhea secondary to steatorrhea.
Deficiency in fat-soluble vitamins.

Point to what diagnosis?
Disorders of absorption of long chain fatty acids
Disorders of absorption of short chain fatty acids (SCFAs
Antibiotics >> suppression of colonic microflora >> decrease SCFA production >> antibiotic-associated diarrhea.
pt presents w/ diarrhea, abdominal pain, cramps. He has normal brush border enzymes and transport functions
Primary (genetic) lactase deficiency.
pt presents w/ diarrhea, abdominal pain, cramps.
She has abnormal brush border enzymes and transport functions
Secondary lactase deficiency
as in small intestinal mucosal disease, e.g. celiac sprue
pt presents w/ diarrhea upon ingestion of glucose or galactose, he has congenital deficiency in brush border transporter SGLT. What is the dx.
Glucose/galactose malabsorption:
8 y/o boy has diarrhea, growth retardation, hypoproteinemia.
Lab tests indicate no activation of trypsinogen to trypsin.
What is the dx?
Enterokinase deficiency:
pt presents w/ hypoproteinemia, pellagra, & neuropsychiatric symptoms. Lab tests show a defect in essential (neutral) amino acid transporter. What is the dx?
hartnup Disease
pt presents w/ hyperaminoaciduria, renal crystals, and no hypoproteinemia. Lab studies show a defect in nonessential (dibasic and Cys) amino acid transporter.
What is the dx
Cystinuria: