Biochem-D/o Of Absorption

Front 1

Disorders of absorption of long chain fatty acids in early digestive stage due to impaired lipolysis(problems with pancreatic lipase):

Back 1

Chronic pancreatitis
Cystic fibrosis
Gastrinoma (pH <7.0)

Front 2

Disorders of absorption of long chain fatty acids in late digestive stage due to errors in conjugation bile acids leading to impaired micelle formation

Back 2

Defects in enterohepatic circulation of bile acids

Front 3

Disorders of absorption of long chain fatty acids in late digestive stage due to errors in conjugation bile acids leading to impaired movement of micelles

Back 3

Thick water layer as in bacterial overgrowth syndromes

Front 4

Disorders of absorption of long chain fatty acids in absorptive stage due to errors of esterification of fatty acids leading to Impaired mucosal uptake & re-esterification

Back 4

Mucosal inflammation as in celiac sprue

Intestinal resection

Front 5

Disorders of absorption of long chain fatty acids in postabsorptive stage due to errors in chylomicron formation

Back 5

Autosomal recessive abetalipoproteinemia which causes acanthocytosis (abnormal erythrocytes due to bad membrane phospholipid content)

Front 6

Disorders of absorption of long chain fatty acids in postabsorptive stage due to Impaired delivery from intestine via lymphatics

Back 6

Abnormal lymphatics as in intestinal lymphangiectasia

Front 7

Clinical manifestations of:
steatorrhea: increase in stool fat excretion to > 6% of dietary fat intake.
weight loss.
Diarrhea secondary to steatorrhea.
Deficiency in fat-soluble vitamins.

Point to what diagnosis?

Back 7

Disorders of absorption of long chain fatty acids

Front 8

Disorders of absorption of short chain fatty acids (SCFAs

Back 8

Antibiotics >> suppression of colonic microflora >> decrease SCFA production >> antibiotic-associated diarrhea.

Front 9

pt presents w/ diarrhea, abdominal pain, cramps. He has normal brush border enzymes and transport functions

Back 9

Primary (genetic) lactase deficiency.

Front 10

pt presents w/ diarrhea, abdominal pain, cramps.
She has abnormal brush border enzymes and transport functions

Back 10

Secondary lactase deficiency
as in small intestinal mucosal disease, e.g. celiac sprue

Front 11

pt presents w/ diarrhea upon ingestion of glucose or galactose, he has congenital deficiency in brush border transporter SGLT. What is the dx.

Back 11

Glucose/galactose malabsorption:

Front 12

8 y/o boy has diarrhea, growth retardation, hypoproteinemia.
Lab tests indicate no activation of trypsinogen to trypsin.
What is the dx?

Back 12

Enterokinase deficiency:

Front 13

pt presents w/ hypoproteinemia, pellagra, & neuropsychiatric symptoms. Lab tests show a defect in essential (neutral) amino acid transporter. What is the dx?

Back 13

hartnup Disease

Front 14

pt presents w/ hyperaminoaciduria, renal crystals, and no hypoproteinemia. Lab studies show a defect in nonessential (dibasic and Cys) amino acid transporter.
What is the dx

Back 14

Cystinuria: