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30 Cards in this Set

  • Front
  • Back
types of proteins that can be absorbed in SI
di, tri & tetra peptides
aa's
where does protein digestion begin
in duodenum with enteropeptidase conversion of trypsinogen to trypsin
pancreatic peptidases
trypsin
chymotrypsin
elastase
carboxypeptidase A & B
activation of trypsin
secreted by pancreas as trypsinogen
activated by enteropeptidase on brush border
characteristics of enteropeptidase
membrane bound
on brush border of SI
serine protease (NOT kinase)
"layers" of peptidases
1st layer
trypsin
chymotrypsin
elastase
carboxypeptidase A & B
2nd layer in cytoplasm
"cytoplasmic peptidase"
digestion of proteins
begins in small intestine
trypsinogen activated by enteropeptidase
trypsin activates other peptidases
cut into di, tri & tetras
transported into cytoplasm
cytoplasmic peptidase
specific aa transporters at basolateral membrane
peptide transporter into enterocyte
Na/K pump at bl memb drives Na out
draws Na in at apical aa's cotransport
PepT1- peptides & H+ in
inability to absorb neutral aa's from SI lumen
(need tryptophan to make niacin so get niacin def)
symptoms include dermatitis exacerbated by sunlight
Hartnup disease
aa transporter with 2 subunits

impaired cationic aa transporter
liver & kidney problems
sx of malnutrition
cystein (def is cysteinuria)
maple syrup urine disease
leucin, isoleucine, valine
absorption of carbohydrates
begins in mouth with alpha amylase (amylose, amylopectin)
hydrolyzed to monosaccharides
SGLT 1 brings glucose & galactose in from lumen
GLUT 5 brings in fructose
transported out of enterocyte by GLUT 2
maltose
2 glucose (alpha 1-4 link)
maltotriose
3 glucose (alpha 1-4 links)
alpha dextrins
short oligosaccharides
lactose
glucose & galactose
sucrose
glucose & fructose
trehalose
glucose
SGLT 1 transporter
Na/K pump at BL membrane (Na out)
SGLT at apex
glucose or galactose and 2 Na come in
GLUT 5 transporter
fructose in
facilitated diffusion
protein disorders
Cysteinuria/lysinuria
Maple Syrup Disease
Hartnup disease
Carbohydrate disorders
GGM
Sucrase Isomaltase Deficiency
Lactase deficiency
Hypolactasia
Celiac Sprue
severe watery diarrhea in infant
resolved if on fructose diet
GGM- glucose/galactose malabsorption
mutation in gene encoding SGLT 1
characteristics of SGLT 1 transporter
14 membrane spanning domains
Glycoprotein (subjected to post transcriptional modification- glycosylation activates or inactivates)
Severe watery diarrhea at about 3 months
resolved with galactose only
Sucrase/Isomaltase Deficiency
(glucose & fructose not absorbed)
diarrhea
releived with removal of lactose
lactase deficiency
hypolactasia
lactose intolerance
starts around 2-5 years
recent mutation allows N Europeans to drink milk
detection of lactose intolerance
lactose tolerance test
stool acidity test
Breath hydrogen test
flattening of lining of SI
poor absorption of nutrients
Celiac Sprue
autoimmune rxn to gluten
1/133 in US
mechanism of diarrhea in carb absorption dz
osmotic
b/c Na & H2O not able to come in