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23 Cards in this Set

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What are the parts and functions of the urinary system?
Kidneys (2) – bean-shaped, fist-sized organ where urine is formed
Ureters (2) – small, muscular tubes that carry urine from the kidneys to the bladder
Bladder (1) – expandable organ that stores urine until it is expelled from the body
Urethra (1) – tube (longer in men than women) that carries urine from the bladder to the outside of the body
Functions of urinary system
1.Excretion of metabolic wastes
2.Maintenance of water-salt balance
3.Maintenance of acid-base balance
4.Hormone secretion: renin and erythropoietin
Excretion
Mostly of nitrogenous wastes:
Urea made by the breakdown of amino acids in the liver
Uric acid made by the breakdown of nucleotides
Creatinine made by muscle cells from the breakdown of creatine phosphate
Maintenance of water-salt and acid-base balance
Both are homeostatic mechanisms
Water-salt balance helps to maintain blood pressure
The kidneys by excreting hydrogen ions and reabsorbing the bicarbonate ions this acid-base balance helps maintain a blood pH of ~7.4
Kidney structure
Renal cortex – an outer granulated layer
Renal medulla – cone-shaped tissue masses called renal pyramids
Renal pelvis – central cavity that is continuous with the ureter
nephrons
Microscopic functional unit of the kidney that produces urine
> 1 million per kidney
Glomerulus
a knot of capillaries inside the glomerular capsule where pores produce a blood filtrate
Proximal convoluted tubule
epithelial layer with a brush border of microvilli to allow reabsorption of filtrate components
loop of nephron
U-shaped structure that has a descending limb to allow water to leave and an ascending limb that pushes out salt
distal convoluted tubule
made of epithelial cells rich in mitochondria and thus is important for movement of
Collecting ducts
several nephrons share a collecting duct which serve to carry urine to the renal pelvis
What are the 3 processes in the formation of urine?
Glomerular filtration
Tubular reabsorption
Tubular secretion
Glomerular filtration
Water and small molecules move from the glomerulus to the glomerular capsule while large molecules and formed elements remain in the glomerular blood
Tubular reabsorption and secretion
Many molecules and ions are reabsorbed from the nephron into the blood
A second way to remove substances such as drugs, H+ and creatinine from the blood
Reabsorption of salt
increases blood volume
Atrial natriuretic hormone (ANH)
secreted by the heart when blood volume increases and inhibits the secretion of aldosterone which promotes the excretion of Na+
Establishment of solute gradient
a greater concentration is towards the inner medulla
Reabsorption of water
due to the solute gradient water leaves the descending limb of the loop of the nephron then antidiuretic hormone (ADH) from the pituitary plays a role in water reabsorption at the collecting duct
What role does alcohol play in this process?
Alcohol inhibits ADH secretion and thus increases the amount of urine and dehydration
How is the acid-base balance maintained?
Buffers are a chemical or a combination of chemicals that can take up excess H+ or excess OH-
Kidney function disorders
Diabetes, hypertension and inherited conditions are the most common cause of renal disease and failure such as:
Urethritis – localized infection of the urethra
Cystitis – infection in the bladder
Pyelonephritis – infection of the kidneys
Kidney stones – hard granules formed in the renal pelvis due to UTI’s, enlarged prostate, pH imbalances or intake of too much calcium
Uremia – high levels of urea and other waste substances in the blood that causes a serious condition when water and salts are retained due to extensive nephron damage
how can Kidney failure be treated?
Hemodialysis – uses an artificial kidney machine to subtract and add substances to the blood as needed
Continuous ambulatory peritoneal dialysis (CAPD) – used the peritoneal membrane to filter the blood and allows a person to go about their normal life without interruption
Kidney replacement – single kidney transplant with a high success rate
_____________________________________
How do the kidneys maintain homeostasis?
Excrete wastes
Urea, creatinine and uric acid
Water-salt balance of blood
Helps regulate blood volume and pressure
Acid-base balance of blood
Helps regulate pH
Assistance to other systems
Endocrine, cardiovascular, skeletal, muscular, nervous and digestive