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19 Cards in this Set
- Front
- Back
Ligands of RTK pathway have the function of:
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Make cell proliferate and eventually differentiate
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Ligands of RTK activate:
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intrinsic kinase activity of transmembrane cell surface receptors
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Ligand binding of RTK does so by
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dimerization of receptor
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Phosphotyresines serve as
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docking sites for adapter proteins
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Adapter plus ___ couples RTKs to other components of signaling pathway
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Ras Protein
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Role of Adaptor proteins
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no enzymatic signaling activity, couple RTKs to other proteins in pathway, scaffold proteins
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3 types of adaptor proteins
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One SH2 domain (recognizes phosphorylated tyrosine, binds residue to C-Terminal) & two SH3 domains (recognizes Pro-rich sequences, binds SOS via SH3 domains
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Activation of GTP is accelerated by:
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Guanine exchange factor (GEF)
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Deactivation of G-Protein by
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GAP (GTPase Activating Protein) (NF1)
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What does MAP kinase Pathway accomplish
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Signal pass from Ras to protein Kinase cascade, activated by phosphorlation of Thr & Try residues
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What is the Map Kinase Cascade pathway? (steps)
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RTK -> Ras ->Raf -> MEK -> MAPK (Erk1 & Erk2)
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Ras activation leads to downsteam signaling known as
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MAPK cascade, which activates many transcription factors
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What does activation of MAPK Erk1 & Erk2 lead to?
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phosphorylation of Ternary complex factor (TCF) and Serum response factor (SRF)
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Adrenergic Receptor Pathway steps:
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Signal=catecholamines
Receptor=GPCR Intracellular transduction=adenylyl cyclase Second messanger=cAMP Response=release of stored energy |
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beta receptors are:
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stimulatory
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alpha2 receptors are
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inhibitory
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what activates the GPCR
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binding of hormone induces a conformational change in the receptor
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what does cAMP do?
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has different effects in different cell types mediated by regulating the activity of enzymes
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PKA is?
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cap-dependant protein kinases, causing a net affect of ATP
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