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4 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Isoproterenol (MOA & PK)
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MOA - Increases inotropy and chronotropy; vasodilation (lowers PVR)
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PK - IV; very short half-life (minutes); degraded rapidly by COMT and MAO; Catechol moiety prevents ready absorption and CNS penetration; B1=B2>>>>>a
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Isoproterenol (CU & T)
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CU - Bradycardia (atropine-resistant); heart block
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T - Palpitations, tachycardia, headache, flushed skin, cardiac ischemia, arrhythmias
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Dobutamine (MOA & PK)
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MOA - B1 agonist with mixed a-agonist/antagonist activity; more prominent inotropic and chronotropic effects (small change in PVR)
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PK - IV; very short half-life (minutes); degraded rapidly by COMT and MAO; Catechol moiety prevents ready absorption and CNS penetration; B1>B2>>>>>a
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Dobutamine (CU & T)
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CU - Heart failure
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T -Palpitations, tachycardia, headache, flushed skin, cardiac ischemia, arrhythmias, more pressure effects
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