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39 Cards in this Set
- Front
- Back
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define congenital infection |
Infection of the fetus in utero followingfrom primaryinfection ofmother, entrance of microorganisms into blood, establishment of infection inthe placenta, invasion into the fetus |
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congenital infections in mother |
mild or unnoticed |
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wht kind of microbiome exists in congenital infections |
placental |
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list of congenital infections |
CMV Rubella toxoplasma gondii treponema pallidum hiv parvovirus B19 VZV listeria monocytogenes |
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what falls under routine antenatal screening |
rubella AB treponema AB Hep B surface antigen HIV AB |
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when is the risk for fetal infection increased |
mom develops poor immune response to infectious agent [infectious agent] in moms blod is high during primary infection |
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when is fetus most susceptible to rubella |
during first 3 months of pregnancy |
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most common manifestation of rubella in infant |
deafness |
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what do infected infant w rubella make |
IgM found in cord blood |
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what helps control the spread of rubella to an infant |
maternal IgG along w interferons |
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when do you vaccinate a pregnant mom for rubella |
never during preg do it immediately after preg vaccinated moms protect future fetus' |
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when are most fetuses usually infected w CMV |
following primary maternal infection |
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most women w CMV are what |
asymptomatic |
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first trimester primary infection w CMV usually results in what |
hearing loss in baby |
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when may a baby be protected from CMV |
during CMV reactivation or re infection in preg due to presence of maternal IgG |
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when and how do you diagnose CMV |
w/in 3 weeks after delivery look for CMV specific IgM in blood or detect and quantify CMV DNA in blood or urine |
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CMV has been tied to what in babies w low birth weight |
breast milk |
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treatment for CMV in babies |
antivirals like ganciclovir, valganciclovir |
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how is HIV passed to babies and how can you prevent it |
vertical transmission (trasplacental, intrapartum, postpartum) avoid invasive procedures |
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triad of HSV symptoms in baby |
skin vesicles or scarring eye disease (chorioretinitis/keratoconjuctivitis) microcephaly (small brain or head size) or hydraencephaly |
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most common time and route of infection for HSV |
delivery |
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clinical findings in VZV |
limb hypoplasia cutaneous scars chorioretinitis cataracts cortical atrophy microcephaly |
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ultrasound of a feetus w VZV a=may reveal what |
hydrops (organs filled w fluid) organ calcification limb deformities |
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when is the VZV contraindicated |
during preg bc it is live attenuated |
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when is HBV infection of baby most likely to occur |
if maternal infection is in the 3rd trimester |
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what is HBV more likely to develop into |
HCC or chronic hep B |
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babies w HBV show what |
hepatosplenomegaly jaundice icterus |
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infection in utero by parvovirus B19 can result in what |
fetal death nonimmune fetal hydrops birth defects |
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when will you see structural anomalies like saddle shaped nose |
syphilis |
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what will you find in the blood of infants w syphilis |
treponemal IgM |
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where does toxoplasmosis like to form abscesses |
nervous system |
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clinical features of congenital infection w toxoplasmosis |
hydrocephaly mental retardation jaundice |
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when do you see signs of toxoplas. in infants |
not t birth but a few yrs later |
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when is baby most likely to be infected w toxoplasmosis |
if mom is infected in third trimester |
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treatment of toxo in women or infected infant |
use spiramycin (stops pro. Synth) or sulphadiazine + pyrimethamine(both stop folic acid synthesis) +folinic acid (additive to help maintain the pts.Folic acid levels to prevent neural tube deficits) |
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is there a vaccine for toxoplasmosis |
no |
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prevention of toxoplas |
avoid primary infection via ingestingcysts from catfeces or lightly cooked meat during pregnancy |
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transmission of listerosis |
contact with infected animalsand their feces,consumption of unpasteurized milk or soft cheeses or contaminated vegetables |
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maternal infection w listerosis can lead to what |
Maternal infection leads to bacteremiawhich can lead to a meningitis, then to placenta, then to fetus |
