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16 Cards in this Set
- Front
- Back
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What wavelength of light is emitted by a Woods lamp? Spectrum? |
365nm
UVA |
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Classification of vitiligo?
1. 2. 3. 4.
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Classification of vitiligo?
1. focal- 1 spot 2. unilateral/segmental- MC variant in children (kids won't have thyroid problems) 3. vulgaris- bilateral (what I had) 4. universal |
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What is the most significant ocular abnormality with vitiligo? |
uveitis |
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Vogt Koyanagi Harada Syndrome? |
polio and vitiligo, severe uveitis, aseptic meningitis, otic involvement
d/t death of melanocytes |
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Alezzandrini syndrome? |
UNILATERAL
white scalp hair, eyebrows, eyelashes, piebaldism all on the same side as unilateral vision changes |
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Most common secondary issue with vitiligo? |
Autoimmune disorders!! MC thyroid |
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APECED mutation? |
Autoimmune polyendocrinopathy candidiasis ectodermal dystophy
mutation on AIRE gene on ch21 (usually confers immune tolerance)
a/w recurrent infections, pernicious anemia, hypothyroidism, alopecia, vitiligo, dysfunction of parathyroid and adrenal glands (hypocalcemia, addissons)
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TX of vitiligo? |
1. NBUVB- TOC, 311nm 2. PUVA- m/c oral psoralin is 8-MOP 3. topical steroids |
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Mutations in:
OCA1a OCA1b OCA2 OCA3 OCA4 OA1 |
OCA1a- TYR absent OCA1b- TYR decreased OCA2- P gene OCA3- TYRP OCA4- MATP (SLC45A2) OA1- OA1 |
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Piebaldism + deafness? |
Woolf syndrome |
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Mutation in Griscelli type 1 |
Myo5a
defect in melanosome trafficking |
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Mutation in Griscelli type 2 |
RAB27A
defect in melanosome trafficking |
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Mutation in Griscelli type 3 |
MLPH
defect in melanosome trafficking |
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Ash leaf spot? |
tuberous sclerosis
AD disorder characterized by hamartomas in skin, brain, eyes, heart |
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Gene defect in incognentia pigmenti? |
NEMO |
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Percentage of heart defects in hypomelanosis of Ito? |
30% |
