Vitiligo Case Study Essay

RESULTS
Studied population
Clinical data of the studied cases were summarized in Table 1.
Table 1: Clinical data of the studied vitiligo patients
Variables
Vitiligo cases
No (%)
35 (100)
Age
Mean ±SD
Median
Range
29.8±16.8
24
10-66
Gender
Male
Female
M:F ratio
12 (34.3)
23 (65.7)
12:23
Occupation
Housewife
Worker
Student
15 (42.9)
8 (22.9)
12 (34.2)
Family history
Positive
Negative
7 (20)
28 (80)
Associated diseases
Associated
Not
10 (28.6)
25 (71.4)
Distribution (types)
Acrofacial
Segmental
Focal
Generalized
8 (22.9)
14 (40)
6 (17.1)
7 (20)
Duration
Mean ±SD
Median
Range
62.7±90.5
36
1- 420
VASI
Mean ±SD
Median
Range
2.9±2.3
3
0-10
VIDA
0
+1
+2
+3
+4
9(25.7)
6 (17.1)
4 (11.4)
7 (20)
9 (25.7)
M:F ratio: Male to …show more content…
It showed cytoplasmic pattern in 23 cases (65.7%) and nuclo-cytoplasmic pattern in 12 cases (34.3%). Epidermal localization occupied the whole thickness in 15 cases (42.85%) and the basal cell layer in 20 cases(57.1%). Epidermal H score had a mean ± SD value of 85.4±47.9. Epidermal H score category is low in 31 cases (88.6%) and high in 4 cases (11.4%) (Table …show more content…
The dermal adnexal LXR-α expression was positive in all of them. All of them showed cytoplasmic pattern and all occupied the whole thickness. dermal H score had a mean ± SD value of 67±33. Dermal H score category is low in all cases (Table 2).
(3) Lesional skin
(a) Epidermis: Epidermal expression was positive in all cases. Epidermal pattern was cytoplasmic in 8 cases (22.9%) and nucleocytoplasmic in 27 cases (77.1%). Epidermal localization occupied the whole epidermal thickness in 14 cases (40%) and the basal cell layer in 21 cases (60%). Epidermal H score had a mean ± SD value of 113.4±50.8. Epidermal H score category is low in 25 cases (71.4%) and high in 10 cases (28.6%) (Table 2).
(b) Dermis: 14 of the examined samples contained dermal adnexa. The dermal adnexal LXR-α expression was positive in all of them. All of them showed cytoplasmic pattern. Dermal localization occupied the whole thickness in 10 cases and the outer root sheath in 4 cases Dermal H score had a mean ± SD value of 79.29±41.04. Dermal H score category is low in all cases (Table 2).
Comparison of LXR-α expression in studied