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11 Cards in this Set
- Front
- Back
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Clostridium difficile |
Toxins A (enterotoxin) and B (cytotoxin) Damage the intestinal mucosa Pseudomembranous colitis Diarrhoea |
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Bacillus anthracis |
Anthrax toxin (three-protein exotoxin) (1) Protective antigen (2) Edema factor (3) Lethal Factor ATP --> cAMP in host cell Inhibits Immune Response |
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Vibrio cholerae |
Cholera toxin ADP-Ribosylation activates host Adenylate Cyclase (ATP --> cAMP). ATP-mediated efflux of chloride ions and water Watery diarrhoea |
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E. coli |
Heat Labile Toxin ADP-Ribosylation activates host Adenylate Cyclase (ATP --> cAMP).ATP-mediated efflux of chloride ions and water Watery diarrhoea |
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Corynebacterium diptheriae |
Diphtheria Toxin Inhibits protein synthesis and kills susceptible cells |
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Pseudomonas aeruginosa |
Exotoxin A (ETA) Inhibits protein synthesis and kills susceptible cells |
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Bordetella pertussis |
(1) Pertussis Toxin Involved in the colonisation of the respiratory tract and the establishment of infection. (2) Adenylate cyclase toxin (CyaA) ATP --> cAMP in host cellInhibits Immune Response (3) Dermonecrotic Toxin Inflammation and local necrosis |
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Clostridium botulinum |
Botulinum neurotoxin
Most acutely lethal toxin known Paralysis |
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Bacillus fragilis |
Bacillus fragilis Enterotoxin Acute inflammatory response in the intestinal mucosa |
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Clostridium tetani |
Tetanus Neurotoxin Second most acutely lethal toxin known Enters CNS Rigid Paralysis |
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Shigella dysenteriae/ E. coli O157 |
Shiga Toxin Inhibits protein synthesis |
