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45 Cards in this Set
- Front
- Back
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H1 sites |
Endothelium Skin nerve ending Smooth muscles Brain |
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H1 functions |
1-VD & ++permiability 2-bronchoconsterction 3-skin itching and urticaria |
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H3 |
Presynaptic |
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H4 |
Chemotaxis |
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H2 sites |
Gastric mucosa Cardiac muscle Brain |
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H2 function |
+ve chrono +ino ++HCL & pepsin VD |
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1st generation |
Dimenhydrinate Diphehydramine Cyclizine Clemastine meclizine Cyproheptadine Promethazine
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2nd generation |
Foxofinadine Loratadine cetirizine |
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Atropin like action |
Antihistamines 1st generation |
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Histamine and serotonin receptor blocker (فيل زوغييَّر) |
Cyproheptadine |
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Action of 1st generation on CNS |
Sedation Antiparkinsonism Local anethetic |
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Autonomic Actions of 1st generation |
Alpha blocker Atropine like |
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Nusea and vomiting in pregnancy |
Doxylamine Meclizine |
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Receptor w' mediate the powerful VC effect of seritonin |
5HT2 |
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Receptor w' mediate Reflex bradycardia effect of seritonin
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5HT3 |
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The Receptor w' platelets aggregation effect of seritonin |
5HT2 |
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The Receptor w ' mediate the peristaltic effect of seritonin & +of ACH release |
5HT2 5HT4 |
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Anxiolytic drugs (T) 🧠 |
Buspirone Endral(propanolo) Benzodiazepine |
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Somatreptan Zolmitriptan |
VC Acute migraine attacks Short duration Contraindicated in angina, hypertension, peripheral vascular disease, pregnancy |
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DexFenfluramine |
As Fenfluramine |
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Itopride |
GERD(gasro-eosophegeal reflex disease) |
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Fluxetine Fluxamine |
Seritonin reaptake inhibitors |
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Prophylaxis of migraine T🧠 |
Cyproheptadine Endral Flunarizine (ca channel blocker) |
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Odansetiron, granisetrone |
5HT3 blocker Antiemitic |
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Ttt of migraine T🧠 |
Ergotamine(hazardous in pregnancy) Samtreptan Zolmitriptan |
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Bromocriptine cebergoline |
Hyperprolactenimia |
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Ergometrine |
Oxytosin like Postpartum hge |
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Ttt of ergotamine overdose or toxisity |
Nitroprusside Nitroglycerin |
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Neurotensin |
Vasodilatador peptide |
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Neuropeptide Y |
Vasoconstruction Why u dont eat |
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Enalkrin remikirin |
Renin receptor blocker |
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ACE inhibitors |
Captopril Lisinopril Enalapril |
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AT1 receptor blockers |
Losartan Valsartan Candesartan Telmisartan (low value candy) +sartan |
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Side effect of ACE inhibitors |
Dry cough due to irritation of kinins |
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Inhibit kallidin enzyme ▶️--kinins synthesis |
Asperin |
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Reflex bradycardia ▶️? Reflex hypotension ▶️? |
Reflec bradycardia ▶️ seritonin action on 5HT3 receptor Reflex hypotension ▶️ kinins and histamine |
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COX1 |
Renal VD Magor role in protection against HCL ++mucus, VD Blocked by aspirin, cortizol |
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COX 2 |
Inflammation Blocked by asperin,cortizol celecoxib IS SPEClFIC blocker |
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COX3 |
CNS Pain and fever Blocked by asperin & cortizol PARACETAMOL IS SPECLFIC BLOCKER |
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Dinoprostone |
PGE2 Labor and aportion |
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Alprostadil |
PGE1 Treatment of erectile dysfunction Mantain potency of ductus arteriosus |
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Misoprostole |
PGE1 Drug of choice for ttt of NSAID induced peptic ulcer استعماله بالوقت الحالي aportion |
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Epoprostenol |
PGI2 Pulmonary hypertension |
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Latanoprost |
Open angle glucoma |
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Dazoxiben |
Inhibit thromboxane synthesis and platelet aggregation |
