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15 Cards in this Set
- Front
- Back
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cholinesterase inhibitors (reverse inhibitors)
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used for moderate duration and treats myasenthia gravis, alzheimers, and parkinson's
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cholinesterase inhibitors (irreversible inhibitors)
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echothiophate (Phospholine Iodide) used for long duration and treats glaucoma
pralidoxime (2-PAM) is used to reverse the effect of echothiophate |
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cholinesterase inhibitor
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prototype: neostigmine (Prostigmin)
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ambenonium (Mytealase)
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cholinesterase inhibitor
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pyridostigmine (Mestinon)
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cholinesterase inhibitor
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edrophomium (Tensilon)
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cholinesterase inhibitor
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cholinesterase inhibitor MOA
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inhibits cholineserase form inactivating acetylcholine, thereby increasing amount of Ach available at receptor sites
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neostigmine uses
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treats myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
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ambenonium
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treatment of myasenthia gravis
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pyridostigmine
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treatment of myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
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edrophonium
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diagnosis of myasenthia gravis
reversal of ND neuromuscular blocking agents |
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cholineserase inhibitors adverse
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excessive muscarine stimulation as evidenced by increased GI motility, secretions
bradycardia, and urinary urgency adverse effects may be treated with atropine cholinergic crisis- can be treated with atropine provide ventilary support |
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cholinesterase inhibitors contraindications
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obstruction of GI and renal
caution in seizure disorders, hyperthyroidism, PUD, asthma, bradycardia, hypotension |
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cholinesterase inhibitors interactions
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atropine counteracts neostigmine
neostigmine reverses neuromuscular blockade caused by neuromuscular blocking agents after surgical procedures of overdose succinylcholine- avoid concurrent use |
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cholinesterase inhibitor effectiveness
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fewer episodes of fatigue
improvement in strength of chewing, swallowing, and performing ADLs |
