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15 Cards in this Set
- Front
- Back
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what is arteriosclerosis?
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Thickening/hardening of arteries
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What is Atherosclerosis?
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Thickening/ hardening of medium-large vessels
ie aorta, coronary, cerebral |
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What happens after LDLs cross endothelium?
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Get oxidized into proinflamatory compounds which attract leukocytes
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how does the endothelium get injured?
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-HTN -High cholesterol
-smoking -toxins -viruses -immune rxns |
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What do the leukocytes do after crossing the endothelium?
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monocytes=> LDL eating macrophages "foam cells"
initiate inflammatory response |
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what is an aggregation of foam cells called?
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fatty streak
*can be seen early in life |
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how do fibrous plaques form?
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Growth factors released by macrophages stimulate production collagen which grows over fatty streak
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How does a complicated plaque occur?
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1) inflammation activates proteinases which rupture plaque
2) exposed tissue triggers clotting cascade => rapid thrombus formation |
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S&S of Atherosclerosis?
(related to perfusion) |
* ischemia of tissues => infarction
* exercise induced angina * High BP |
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what types of meds are gven for atherosclerosis?
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Meds aimed at lowering BP and decreasing cholesterol
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what are common causes for Coronary Artery Disease?
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HTN and atherosclerosis
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CAD- Unmodifiable risk factors
(3) |
over 65
gender genetic predisposition |
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CAD- modifiable risk factors
(5) |
*Cholesterol > 200
*HTN *smoking(vasoconstriction, inc BP, HR, HTN) *sedentary (low HDL) obesity (high LDL) |
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CAD Treatment
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reduce risk factors
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Danger of CAD
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can progress to angina or myocardial infarction
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