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9 Cards in this Set
- Front
- Back
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Asthma is characterized by: |
Airway hypersensitivity Airway inflammation Airway remodeling |
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Pathophysiology (immediate phase and late phase) |
immediate phase: activation of mast cells and macrophages to release LT and histamines late phase: recruitment of innate immune cells to continue bronchoconstriction and epithelial damage |
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B2 agonists |
Gs activation increase CAMP phos. PKA and IP3 for MLCP activation for relaxation (olols) |
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Musc. antagonists |
prevent acetylcholine stim. of airway smooth muscle (atropines) |
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Methylxanthines |
Inhibit phosphodiesterase to decrease CAMP breakdown (theophylline) |
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corticosteroids |
reduce inflammatory mediators via transcriptional regulation (prednisone, flunisolide) |
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LT inhibitors |
Inhibit LT synthesis or antagonize receptors to prevent SM contraction, airway inflam, and mucus secretion (zileuton or zafirlukast) |
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Mabs |
Form complex with IgE to prevent mast cell activation Omalizumab Could also complex inflam. mediators |
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Combination therapy |
bronchodilator + anti-inflammatory |
