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47 Cards in this Set
- Front
- Back
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An increase in airway resistance in asthmatic patients can be caused by the following EXCEPT:
a. inhaled epinephrine b. mucus hypersecretion c. edema d. inhalation of sulfur dioxide (2003 exam 4 q5) |
a. inhaled epinephrine
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The following are the substances released by mast cells upon exposure to an antigen. Which one is responsible for the disruption of the epithelial tight junction?
a. histamine b. Leukotriene C4 c. PAF d. Tryptase e. none of the above (2003 exam 4 q6) |
d. tryptase
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Which of the following cell types is responsible for the late phase of asthma?
a. eosinophil b. mast cell c. macrophage d. TH1 cell e. TH2 cell (2003 exam 4 q7) |
e. TH2 cell
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Which of the following cytokines is the most likely candidate responsible for airway hyperreactivity in the late phase of asthma?
a. INFy b. IL-4 c. IL-5 d. IL-9 e. IL-13 (2003 exam 4 q8) |
e. IL-13
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An asthma drug used mainly for the prophylactic purpose is:
a. theophylline b. cromolyn sodium c. ipratropium bromide d. albuterol e. budesonide (2003 exam 4 q9) |
b. cromolyn sodium
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Which of the following is NOT TRUE about beta2 agonists:
a. onset of action is relatively fast (e.g., faster than theophylline) b. the short acting ones last 3-4 hours whereas the long acting ones last 12 hours or longer c. salmeterol is a long-acting beta2 agonist d. the long acting beta2 agonists can be used for prevention of the nocturnal asthmatic attack e. R isomers are equipotent with S isomers (2003 exam 4 q10) |
e. R isomers are equipotent with S isomers.
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The following pairs represent drugs used in the treatment of asthma and their possible mechanisms of action. Which pair is not true:
a. steroids - decrease in the production of leukotriene D4 b. cromolyn sodium - inhibition of degranulation of mast cells c. salmeterol - stimulation of adrenergic beta2 receptors d. ipratropium bromide - blockade of cholinergic receptors e. theophylline - inhibition of PDE and/or inhibition of A2 receptors (2003 exam 4 q11) |
e. theophylline - inhibition of PDE and/or inhibition of A2 receptors
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Montelukast (Singulair):
a. highly effective for all types of asthmatic patients b. a 5-lipoxygenase inhibitor c. a LTD4 synthesis inhibitor d. an effective chemotactic agent e. none of the above (2003 exam 4 q12) |
e. none of the above
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The following factors contribute to airway obstruction EXCEPT:
a. contraction of bronchial smooth muscles b. airway edema c. mucus hypersecretion d. hypoventilation (2004 exam 4 q11) |
d. hypoventilation
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The cell type responsible for airway hyperreactivity during the late phase of asthma:
a. TH2 cells b. neutrophils c. bronchial smooth muscle cells d. capillary endothelial cells e. mucus-secreting cells (2004 exam 4 q12) |
a. TH2 cells
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What is the initial (the very first) reaction leading to the asthmatic symptoms:
a. epithelia cell damage b. recruitment of neutrophils into the airway c. release of histamine from mast cells d. mucus hypersecretion e. antigen-binding to IgE (2004 exam 4 q13) |
e. antigen-binding to IgE
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Which of the following is used for the prophylactic use in the treatment of asthma?
a. theophylline b. cromolyn sodium c. ipratropium bromide d. triamcinolone e. albuterol (2004 exam 4 q14) |
b. cromolyn sodium
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Which one is the most effective in the treatment of the late phase of asthma?
a. theophylline b. cromolyn sodium c. ipratropium bromide d. triamcinolone e. albuterol (2004 exam 4 q15) |
d. triamcinolone
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The following pairs represent drugs used in the treatment of asthma and their possible mechanisms of action. Which pair is not true:
a. salbutamol - stimulation of adrenergic beta1 receptors b. theophylline - inhibition of PDE and/or inhibition of adenosine c. ipratropium bromide - blockade of cholinergic receptors d. cromolyn sodium - inhibition of mast cell degranulation e. steroids - inhibition of phospholipase A2 (2004 exam 4 q16) |
a. salbutamol - stimulation of adrenergic beta1 receptors
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Which of the following statments is not true of theophylline:
a. can relax bronchial smooth muscle b. has a low margin of safety c. is administered as an inhaler d. increases intracellular cAMP levels e. can stimulate gastric acid secretion (2004 exam 4 q17) |
c. is administered as an inhaler
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The following substance have an ability to contract bronchial smooth muscles except:
a. histamine b. PAF c. substance P d. leukotriene B4 e. leukotriene C4 (2004 exam 4 q18) |
d. leukotriene B4
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Which of the following drugs is most effective in aspirin-induced asthma?
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. zafirlukast (2004 exam 4 q19) |
e. zafirlukast
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The following agents are involved either directly or indirectly in the pathogenesis of asthma except:
a. dopamine b. histamine c. substance P d. acetylcholine e. adenosine (2002 exam 4 q10) |
a. dopamine
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The following components are involved in airway neurogenic inflammation except:
a. irritant receptors in the airway b. sensory fibers c. antidromic pathway d. release of neurokinins e. activation of sympathetic neurons (2002 exam 4 q12) |
(DOUBLE-CHECK)
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Which of the following statements is not true about theophylline:
a. inhibits only A1 receptors (but not A2 receptors) b. Inhibition of A1 receptor results in a decrease in cAMP c. has a low therapeutic index d. 10-20 mcg/ml in plasma inhibits the PDE activity in bronchial smooth muscles e. Its base is only slightly soluble in water (2002 exam 4 q13) |
(DOUBLE-CHECK)
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Which of the following anti-asthmatics can be used prophylactically?
a. theophylline b. ipratropium bromide c. beclomethasone d. cromolyn sodium e. metaproterenol (2002 exam 4 q14) |
d. cromolyn sodium (DOUBLE-CHECK)
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Which of the following statements is not true about salmeterol:
a. beta2 agonist b. increases cAMP in bronchial smooth muscle cells c. relaxes bronchial smooth muscle d. peaks at about 30 minutes and lasts for 3-4 hours e. its R form is more potent than its S form in its ability to increase cAMP (2002 exam 4 q15) |
d. peaks at about 30 minutes and lasts for 3-4 hours
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What is the mechanism of action of montelukast (Singulair) in its use as an anti-asthmatic drug:
a. inhibition of arachidonic acid synthesis b. inhibition of lipoxygenase c. antagonism of a leukotriene receptor d. suppression of degranulation of inflammatory cells e. immune suppression (2002 exam 4 q16) |
c. antagonism of a leukotriene receptor
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The following substances are found in the asthmatic lung. Which of the following statements is not true about their effects in the airway: a. substance P contracts bronchial smooth muscles
b. leukotriene B4 is a potent chemotactic agent c. PAF contracts bronchial smooth muscles d. histamine increases capillary permeability e. adenosine relaxes bronchial smooth muscle (2001 exam 3 q31) |
e. adenosine relaxes bronchial smooth muscle (DOUBLE-CHECK)
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Which of the following neurotransmitters is involved in neurogenic inflammation?
a. acetylcholine b. epinephrine c. substance P d. dopamine e. serotonin (2001 exam 3 q32) |
a. acetylcholine (DOUBLE-CHECK)
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The following are directly associated with the early phase of asthma except:
a. release of histamine from mast cells b. opening of tight epithelial junctions c. mucosal edema d. increased mucus secretion e. increase in the number of eosinophils in the airway (2001 exam 3 q33) |
e. increase in the number of eosinophils in the airway
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Which of the following drugs is most effective during the sudden asthmatic attack?
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. dextromethorphan (2001 exam 3 q35) |
d. terbutaline
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Which of the following drugs is most effective in aspirin-induced asthma?
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. zafirlukast (2001 exam 3 q36) |
e. zafirlukast
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Which of the following drugs is prophylactic for asthma?
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. montelukast (2001 exam 3 q37) |
a. cromolyn sodium (DOUBLE-CHECK)
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Which of the following drugs has the lowest therapeutic index:
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. ipratropium bromide (2001 exam 3 q38) |
c. theophylline
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Which of the following drugs has a quaternary ammonium in its structure:
a. cromolyn sodium b. beclomethasone c. theophylline d. terbutaline e. ipratropium bromide (2001 exam 3 q39) |
e. ipratropium bromide
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Which of the following neurotransmitters is most active in controlling 'normal' airway smooth muscle tone?
a. norepinephrine b. dopamine c. acetylcholine d. histamine e. adenosine (2002 quiz 13 q1) |
c. acetylcholine
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The following can result in airway narrowing in 'normal' adults except:
a. stimulation of efferent vagus nerve innervating the airway b. inhalation of sulfur dioxide c. neurogenic inflammation d. increased capillary permeability e. running a 100 meter distance (2002 quiz 13 q2) |
e. running a 100 meter distance
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Which of the following is not true of theophylline:
a. is used in the treatment of asthma b. is relatively safe c. can relax bronchial smooth muscles d. increases cAMP inside the bronchial smooth muscle cell e. its use has recently been drastically reduced. (2002 quiz 13 q3) |
b. is relatively safe
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The following drugs are available for inhalation except:
a. theophylline b. fluticasone propionate c. albuterol d. cromolyn sodium e. ipratropium bromide (2002 quiz 13 q4) |
a. theophylline
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Which of the following cell types increase drastically in the airways during the late phase of asthma:
a. basophils b. eosinophils c. neutrophils d. monocytes e. RBCs (2002 quiz 13 q5) |
b. eosinophils
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The following cytokines are released by TH2 cells except:
a. interferon gamma b. IL-4 c. IL-5 d. IL-9 e. IL-13 (2002 quiz 13 q6) |
a. interferon gamma
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T/F: asthma is an inflammatory disease.
(2003 quiz 13 q1) |
true
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T/F: macrophage is the first cell type that interacts with an inhaled antigen.
(2003 quiz 13 q2) |
false
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T/F: the inhaled antigen reacts with IgG molecules present on the cell surface to initiate the immune response.
(2003 quiz 13 q3) |
false
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T/F: LTB4 is a potent chemotactic agent
(2003 quiz 13 q4) |
true
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T/F: nedocromil sodium is effective immediately after the asthmatic attack.
(2003 quiz 13 q6) |
false
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T/F: theophylline is a purine derivative
(2003 quiz 13 q7) |
true
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T/F: the racemic form of albuterol is as potent as its R form in relaxing the bronchial smooth muscle
(2003 quiz 13 q8) |
false
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The duration of action of salmeterol when used as an asthma drug is approximately 4 hours.
(2003 quiz 13 q9) |
false
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T/F: zileuton is a new generation of asthma drug which inhibits cyclooxygenase
(2003 quiz 13 q10) |
false
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T/F: during the late phase of asthma there is always an increase in the number of eosinophils in the airways.
(2003 quiz 13 q5) |
true
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