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20 Cards in this Set
- Front
- Back
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Zidovudine |
AKA AZT Nucleoside reverse transcriptase inhibitor Thymidine analogue C/I with stavudine |
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Side Effects of Zidovudine |
Headache Nausea Anaemia -- monitor, stop if severe Granulocytopaenia -- stop if severe Myopathy -- stop if severe Nail discoloration |
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Stavudine |
AKA d4T NRTI Thymidine analogue C/I with zidovudine and didanosine |
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Side Effects of Stavudine |
Peripheral neuropathy -- dicontinue if severe Pancreatitis -- discontinue if confirmed Macrocytosis Lipoatrophy |
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Didanosine |
AKA ddi NRTI Adenosine analogue C/I with stavudine -- causes lactic acidosis |
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Didanosine Side Effects |
Pancreatitis -- discontinue if confirmed and severe Peripheral neuropathy -- discontinue if severe Abdominal cramps -- evaluate for pancreatitis |
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Zalcitabine |
ddC NRTI Cytidine analogue |
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Lamivudine |
3TC NRTI Cytidine analogue Used in PEP along with tenofivir and emtricitabine and a protease inhibitor or raltegravir. |
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Lamivudine Side Effects |
Abdominal pain -- evaluate for pancreatitis Nausea Vomiting |
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Abacavir |
ABC NRTI Guanidine analogue |
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Abacavir Side Effects |
Hypersensitivity -- STOP therapy, reactions are progressive, never re-challenge after hypersensitivity. |
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Nevirapine |
NVP Non-nucleoside reverse transcriptase inhibitor Susceptible to resistance developing as only a single point mutation causes complete resistance and there is crossover resistance within the NNRTI |
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Nevirapine Side Effects |
Rash -- monitor, proceed with caution Stevens Johnson Syndrome -- discontinue of severe Fulminant hepatotoxicity -- monitor, first 6 weeks discontinue. |
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Efavirenz |
EFZ, EFV NNRTI Same susceptibility to resistance as nevirapine |
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Efavirenz Side Effects |
CNS: Anxiety, depression, dysphoria, nightmares -- normally resolve withing 2-3 weeks Rash -- less common than NVP Hepatitis |
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Idinavir Side Effects |
IDV, PI Nephrolithiasis Crystalluria -- evaluate flank pain Haematuria, intersitial nephritis -- increase water intake Nausea, GIT problems Insomnia, dizziness Rash Metallic taste Thrombocytopaenia |
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Ritonavir |
RTV, PI Low dose used to increase bio-availability of other PIs. No longer used as a sole PI in a regimen. |
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Nelfinavir Side Effects |
NFV, PI Diarrhoea GIT disturbance |
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Lopinavir/ritonavir Side Effects |
LPV/r, PI Diarrhoea Skin rash Headache Weakness |
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Saquinavir Side Effects |
SQV, PI Diarrhoea Headache -- increase ritonavir dose |
