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14 Cards in this Set
- Front
- Back
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What are arthropod-borne viruses known as?
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Arboviruses
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What are the 3 main arboviruses encountered in NC?
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West Nile, Eastern Equine Encephalitis virus, and LaCrosse Encephalitis virus
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What type of genome do flaviviruses have?
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positive-sense RNA
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What is the main reservoir for West Nile virus?
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West Nile virus can infect a huge number of different animals, but its largest pool is the bird population.
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What type of virus is West Nile?
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Flavivirus
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What serious condition can WNV cause?
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encephalitis, but 80% of infected people are asymptomatic
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What is the most prevalent arbovirus affecting humans?
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Dengue virus
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What is the life-threatening disease caused by Dengue virus?
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Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)
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What genus of mosquito transmits Dengue?
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Aedes
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Where generally is Dengue mainly found?
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Urban areas of high population density
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What is classic Dengue known as?
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Break-bone fever. It is different than DHF/DSS
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What is the course of DHF?
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It first appears similarly to break-bone fever, but 3-7 days after fever onset the platelet counts decrease and vascular leakage begins. This leads to internal and external hemorrhage.
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Who faces a much greater risk of DHF?
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People with a second infection but by a different serotype of Dengue.
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What mechanism is thought to cause DHF?
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Antibody-dependent enhancement. Cross-reactive antibodies from the first infection don't completely neutralize the second serotype, and actually facilitate the uptake of virus into macrophages. That increases viral replication and inflammation.
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