Apoptosis

Front 1

Basic process of apoptosis

Back 1

1. Cascade of proteolytic events
2. Cell eventually dies from the inside
3. Process is irreversible

Front 2

3 functions of apoptosis

Back 2

1. Balance out cell division
2. Get rid of problem cells
3. Control developmental process

Front 3

Caspases

Back 3

Proteolytic enzymes that mediate the process. They start out as PROcaspases and once they are activated they activate more(initiator)

Front 4

Fas ligand

Back 4

Extracellular signal that binds to fas ligand death receptor and activates caspases

Front 5

3 intracellular signals that induce apoptosis

Back 5

1. Stress
2. Damaged DNA
3. Damaged mt

Front 6

4 signals that tell the process is occurring

Back 6

1. Fragmented DNA
2. Phosphytidylserine on OUTER PM
3. Loss of Voltage across inner mt membrane
4. Cytochrome C in CYTOSOL

Front 7

Mitogens

Back 7

Regulatory proteins that stimulate mitosis

Front 8

Growth factors

Back 8

Regulatory proteins that promote protein synthesis and cell growth. Usually activated by another cell. Stimulate anabolism