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107 Cards in this Set

  • Front
  • Back

DNA

Our genes

How many molecules do most human cells have?

46

Bases to DNA (4)

Adenine, Thymine, Cytosine, Guanine

DNA Base pairs

A-T and C-G

Essential role of DNA

Carry instructions called genes for the synthesis of proteins

Chromatin

Fine, filamentous material complexed with proteins in the nucleus of a cell

RNA

Single helix one nucleotide chain

3 forms of RNA

MessengerRNA


TransferRNA


RibosomalRNA

Base pairs of RNA

A-U (Uracil) C-G

Essential function of RNA

To interpret the code in DNA and use those instructions to synthesize proteins

Gene

Information containing segment of DNA that codes for the production of a molecule of RNA

46 chromosomes

In 2 sets of 23 each, one from each parent

Condon

Sequence of 3 nucleotides that together form a unit of genetic code in a DNA or RNA molecule

3 base sequence in mRNA

Condon

Genetic code expressed in

Condons

Protein synthesis

When a gene is activated a mRNA is made- mirror image of a gene

Step from DNA to RNA is called

Transcription

The step from mRNA to protein

Translation

Translation

MRNA carries genetic code from the nucleus to cytoplasm

Translation occurs in 3 steps

Initiation


Elongation


Termination

Before a cell divides

It must duplicate its DNA so it can give complete and identical copies of its genes to each daughter cell

Some cells divide rapidly such as

Stomach and skin cells

Some cells divide slowly such as

Bone and cartilage

Some cells don't divide at all such as

Skeletal muscle and nerve cells

Cell divided into 4 main parts

G1


S


G2


Mitosis

G1

Almost all tasks happen in G1, during this time synthesizes proteins, grows, and carries out is preordained tasks for the body

S

Cell makes a duplicate copy of its centrioles and all of its nuclear DNA

G2

Checks the DNA and repairs any errors that we made

M- mitosis

4 phases: prophase, metaphase, anaphase, telophase

Heredity

Transmission of genetic characteristics from parent to offspring

Chromosomes occur in? Pairs

23. One from each parent

Recessive allels only expressed...

When present on both chromosomes

Phenotype

Observable trait

Histology

Study of tissues and how they are arranged into orgns

Primary tissue classes

Epithelial


Nervous


Connective


Muscle

Ectoderm

Gives rise to the epidermis and nervous system

Endoderm

Innermost layer of embryonic tissues

Mesoderm

Middle layer embryonic tissue, gives rise to muscle, bone, and blood among other tissues

Epithelial tissue

Covers body surface, lines body cavities, forms the external and internal linings of the many orgns and constitutes most glands

Primary function of epithelial tissue

Protection


Secretion


Excretion


Absorption


Filtration


Sensation

Simple and pseudostratified often have

Goblet cells associated with them and produce protective mucus coatings over mucous membrane

Simple cuboidal epithelium

Single layer of square of round cells: absorb and secrete

Simple squamous epithelium

Single row of thin cells: permit rapid diffusion: secrets serous fluid

Simple columnar epithelium

Single row of tall cells: absorb, secrete mucus

Pseudostratified epithelium

Looks multilayered all touch basement membrane. Secretes and propel mucus

Stratified epithelia

2 or more cell layers thick. Most widespread epithelium in body is stratified squamous epithelium. Come in 2 ways: keratinized or nonkeratinized

Keratinized stratified squamous

Epidermis

Nonkeratinized stratified squamous

Resists abrasion and penetrate of the pathogens

Fibrous Connective tissue

Most diverse type of Connective tissue

Types of fibers (3)

-loose Connective tissue


-areolar tissue


-reticular tissue

Areolar tissue

Found in almost every part of the body, fibers run in random directions and are mostly collagen, most abundant in body

Reticular tissue

Forms framework for organs such as lymph nodes, speen and thymus

Dense Connective tissues (2)

Dense regular tissue


Dense irregular tissue

Dense regular tissue

Closely packed collagen fibers that run parallel to each other, Found in tendons and ligaments

Dense irregular tissue

Closely packed collagen fibers that run in seemingly random directions

Adipose tissue

Primary energy resivoir,adipocytes are primary cell type

2 kinds of fat in human

White- most widespread


Brown- found in fetus and child, highly metabolic, used for heat production

Hyaline cartilage

At the end of long bones attach ribs to sternum

Elastic cartilage EEE

Flexible, Found in the epiglottis and ear

Fibrocartalege

Forms discs, see intervertebral discs, pubic symphysis and knee menisci; resists compression and absorbs shock

Osseous tissue that is hard, calcified Connective tissue

Makes up the skeleton

Spongy bone

Fills the epiphyses of long bones and middle of flat bones

Compact bone

Is denser tissue that forms the external surface of all bones

Blood primary function

Transport of cells, nutrients, gasses and wastes

Nervous tissue

Specialized for forms of communication, by means of electrical and chemical signals.

Muscle tissue

Specialized tissue to contract when stimulated thus exerting a force on other tissues

3 types of muscle

Skeletal- only voluntary muscle group


Cardiac- involuntary


Smooth aka visceral muscle-forms layers in walls of hollow organs

Cell junctions 3 types

Tight junctions


Desmosomes


Gap junctions

Exocrine glands

Have ducts, secretion usually released to body surface or into another organ such as the mouth or intestines

Endocrine glands

Loose contact with body surface and have no ducts, secreting directly into blood

Hyperplasia

Tissue growth (childhood) through cell multiplication

Hypertrophy

Tissue growth through size (muscle)

Damaged tissues can be repaired in 2 ways:

Regeneration


Fibrosis

Regeneration

The replacement of dead or damaged cells by the same type of cells as before and it restores normal function to the orgn

Fibrosis

The replacement of damaged tissue with scar tissue, composed mainly of collagen produced by fibroblasts

Atrophy

The shrinkage of a tissue through a loss in cell size or number

Apoptosis

"Programmed cell death" -normal death of cells that have completed their function and best serve the body by dying and getting out of the way

Integumentary system

Consists of the skin and its accessory organs, hair, nails, cutaneous glands

Dermatology

The scientific study and medical treatment of the integumentary system

Skin functions as

Resistance to trauma and infection


Vitamin D synthesis


Sensation


Thermoregulation


Nonverbal communication

Epidermis

-Keratinized stratified squamous epithelium,


-a vascular, get nutrition via diffusion from underlying Connective tissue


-has sparse nerve endings for touch and pain.

Stem cells

Found only in the stratum basale

Keratinocytes

The great majority of epidermal cells, role in synthesizing keratin

Melanocytes

Only in stratum basale, synthesize brown to black pigment melanin. Pigment shields DNA in stratum basale from UV radiation

Tactile (Merkel) cells

For touch, few in number, the cell and nerve fiber are called Merkel discs

Dendric (langerhans) cells

In stratum spinosum and stratum basale, immune cells that originate from bone marrow

Layers of epidermis (cute little grasshoppers smell bad)

-stratum corneum.2nd layer of epidermis


-stratum lucidum


-stratum granulosum


-stratum spinosum


-stratum basale. Deepest oldest layer

Dermis

Composed mainly of collagen, well supplied with blood vessels, cutaneous glands, and nerve endings

Dermis layers

Papillary layer- contains dermal papilae (fingerprints)


Reticular layer- deeper much thicker, dense irregular tissue, striae (stretch marks) are formed when collagen tears

Melanin

The most significant factor in skin color, eumelanin, pheomelanin, skin color varies on the amount and type of melanin produced, not difference in number of melaninocytes

Red skin

Hemoglobin in blood makes you a little more red. Erythema- abnormal red

Orange skin

Carotene concentrating in subcutaneous fat

Blue skin

Cyanosis from a lack of o2 in blood changing Hgb

White, pallor skin

Decreased blood flow, albinism- genetic lack of pigment

Yellow skin

Jaundice, high levels of bilirubin in the blood, liver disease

Bruise

Hematoma as a mass of clotted blood showing through the skin

Hair

Composed mostly of dead keratinized cells, arrector pili- smooth muscles that extend from dermal collagen fibers to the CT sheath of the hair follicle

Nails

Clear, hard derivatives of the stratum corneum, hard part of nail is Nail Plate

Glands

Sudoriferous glands, sweat glands 2 types

2 sweat glands types

Apocrine


Merocrine/eccrine

Sebaceous glands

Secrete sebum (oil substance)

Ceruminous glands

Secrete cerumen (earwax)

Mammary glands

Secrete milk, Found in breasts; modified apocrine sweat glands

Skin cancer

Most common in head, kneck, places sun sees often

Abcd rule for recognize skin cancer

-Asymmetry, one side different from other


-Border irregularity: contour is not uniform but wavy


-Color; often a mix of brown tan red black


-Diameter; greater than 6mm

3 types skin cancer

-basale cell carcinoma- most common type


-squamous cell carcinoma- arises from keratinocytes of the stratum spinosum


-melanoma- arises from melanocytes; extremely aggressive


Burns

First- only in epidermis


Second- epidermis and part dermis


Third-dermis and deeper tissue