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28 Cards in this Set
- Front
- Back
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HSV & VZV drugs
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acyclovir, foscarnet
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CMV drugs
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ganciclovir, foscarnet
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Influenza drugs
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zanamivir, oseltamivir
amantadine, rimantadine |
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Respiratory Syncytial Virus
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ribavirin
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Hepatitis drugs
HCV & HBV |
HCV: peginerferon alfa, ribavirin
HBV: interferon alfa, lamivudine |
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Herpes viruses are what kind of viruses
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DNA viruses
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For HSV what drugs are most often used and what is the MOA
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Nucleoside Analogs
triphosphate (TP) inhibits viral DNA polymerase |
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What is the key to selective toxicity for HSV, VZV, & CMV drugs
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initial conversion completed by VIRAL KINASE***
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Acyclovir
Use & DOC |
use: HSV-1 & 2, VZV
DOC: HSV encephalitis, neonatal HSV amd serious HSV / VZV |
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Acyclovir
MOA |
phosphorylated by viral thymidine kinase* making triphosphate to inhibit viral DNA syn
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Acyclovir
Tox |
well tolerated
if IV however, Acute renal failure & Neuro/CNS |
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Ganciclovir
Use & MOA |
use: CMV (prevent & Tx)
MOA: initiated by *CMV phosphotransferase then inhibits DNA syn |
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Genciclovir
Tox |
BMD, CNS
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Foscarnet
use & tox |
use: serious HSV & CMV infects (resistance, AIDS)
TOX: nephrotox, hypocalcemia (can cause arrhythmias) |
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Foscarnet
MOA |
NOT a nucleoside analog** and no activation via viral kinase required
inhibits viral DNA polymerase (no chain elongation) |
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What are the drug classes for influenza treatment?
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Neuraminidase inhibitors & Viral uncoating inhibitors
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MOA of Zanamivir & Oseltamivir
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inhibitor of influenza A & B neuraminidase, which prevents release of virus and inhibs viral spread in resp tract
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Use and administration of Zanamivir & Oseltamivir
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influenza A & B (hospitalization and animal strains)
Zanamivir- inhalation Oseltamivir - oral |
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Tox of Zanamivir & Oseltamivir
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Zanamivir: Bronchospasm (inhaled agent)
Oseltamivir: neuropsychiatric (serious in children) |
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MOA of Amantadine / Rimantadine
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prevents uncoating of viral RNA
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Use & administration of Amantadine / Rimantadine
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Influenza A only
Amantadine only enter CNS and also used for Parkinson's |
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Tox of Amantadine / Rimantadine
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GI & CNS (mostly elderly)
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MOA & class of Ribavirin
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UNKNOWN! & very toxic!
guanosine analog |
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Use & admin of Ribavirin
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severe *Respiratory Syncytial Virus* in infants and children & *Hepatitis C*
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Standard of care for Hepatitis C
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Peginterferon alfa & Ribavirin
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Interferon alpha use, MOA, & tox
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use: hepatitic B + C
MOA: turns on gene expression for antiviral effects tox: severe CNS (depression and suicidal behavior) |
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tox of Ribavirin
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oral: anemia
PREGnancy category X = no PREGGOS (or their baby dady's trying to knock them up)! |
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Hepatitis B treatment in US & Europe
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US: Lamivudine
Euro: Interferon alfa |
