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10 Cards in this Set
- Front
- Back
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Describe the life cycle of Plasmodia starting with injection of sporozoites by a female Anophele mosquito.
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1) Sporozoites are injected into the blood of the host.
2) Sprozoites rapidly invade the liver and divide inside the liver to form an exoerythrocytic or hepatic schizont. 3) The schizont ruptures, releasing merozoites into the blood. 4) Merozoites invade rbc's to form erythrocytic schizonts. **Or the protozoa can lie dormant in the liver until later reactivated 5) Merozoites reproduce within the erythrocyte schizonts, and the schizonts rupture, releasing merozoites and pyrogenic factors. 6) Asexual merozoites reinvade the rbc's but some merozoites undergo sexual transformation to form male and female gametocytes which are reingested by the mosquito and the life cycle repeats. |
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Which of the following Plasmodium species forms latent liver infections?
a) P. vivax + P. malariae b) P. ovale + P. malariae c) P. falciparum + P. ovale d) P. vivax + P. ovale |
Which of the following Plasmodium species forms latent liver infections?
d) P. vivax + P. ovale |
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Identify the drug of choice for treatment of the following..
1) prophylaxis for people traveling to regions with chloroquine-resistant P.falciparum 2) prophylaxis for people traveling to regions with P.falciparum that is sensitive to standard therapy 3) eradication of chloroqiune-resistant P.falciparum 4) given to a person returning from a region where P.ovale is endemic in order to eradicate hypnozoites in the liver 5) often the drug of choice for malaria treatment 6) this combination is used to treat mefloquine-resistant P.falciparum |
1) prophylaxis for people traveling to regions with chloroquine-resistant P.falciparum = MEFLOQUINE or doxycycline
2) prophylaxis for people traveling to regions with P.falciparum that is sensitive to standard therapy = CHLOROQUINE 3) eradication of chloroqiune-resistant P.falciparum = MEFLOQUINE OR QUININE 4) given to a person returning from a region where P.ovale is endemic in order to eradicate hypnozoites in the liver = PRIMAQUINE 5) often the drug of choice for malaria treatment = CHLOROQUINE 6) this combination is used to treat mefloquine-resistant P.falciparum = SUFADOXINE + PYRIMETHAMINE |
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This Plasmodium species causes the most severe form of malaria and is also frequently drug resistant.
a) P.vivax b) P.falciparum c) P.malariae d) P.ovale |
This Plasmodium species causes the most severe form of malaria and is also frequently drug resistant.
b) P. falciparum |
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Metronidazole is the drug of choice for the treatment of..
a) pneumocystis jiroveci and Toxoplasma b) asymptomatic E.histolytica and Trichomonas c) Giardia lamblia and Toxoplasma d) Giardia lamblia and Trichomonas e) E.histolytica and Toxoplasma |
Metronidazole is the drug of choice for the treatment of..
d) Giardia lamblia and Trichomonas |
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This is the drug of choice for treatment of asymptomatic E.histolytica infection.
a) iodoqiunol b) metronidazole c) pentamidine d) chloroquine |
This is the drug of choice for treatment of asymptomatic E.histolytica infection.
a) iodoqiunol |
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Pyrimethamine + trisulfapyrimidines is an effective drug combo in treating..
a) E.histolytica b) Trichomonas vaginalis c) Toxoplasma gondii d) Giardia lamblia |
Pyrimethamine + trisulfapyrimidines is an effective drug combo in treating..
c) Toxoplasma gondii |
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What is the mechanism of action of the drug combination, atovaquone+proguanil?
When in combination, the drugs are used to treat (blank). When atovaquone is given alone, it is used to treat (blank). |
Atovaquone disrupts the mitochondrial electron transport while proguanil (once converted to cycloguanil) inhibits plasmodial dihydrofolate reductase.
When in combination, the drugs are used to treat MALARIA. When atovaquone is given alone, it is used to treat PNEUMOCYTIS JIROVECI. |
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Identify the anti-malarial drug associated with the following adverse effects or contraindications.
(Possible answers: chloroquine, mefloquine, primaquine, quinine) 1) can cause reversible corneal damage and permanent retinal damage 2) can cause cinchonism 3) not to be given to people with a history of epilepsy, psych disorders or cardiac conduction defects 4) can cause hemolytic anemia in patients with deficient G6PD enzyme 5) can cause visual distrubances, hyperexcitability, and heart block 6) not be given to a patient with a a history of aconnective tissue disorder or a history of granulocytopenia or methemoglobinemia |
1) can cause reversible corneal damage and permanent retinal damage = CHLOROQUINE
2) can cause cinchonism = QUININE 3) not to be given to people with a history of epilepsy, psych disorders or cardiac conduction defects = MEFLOQUINE 4) can cause hemolytic anemia in patients with deficient G6PD enzyme = PRIMAQUINE 5) can cause visual distrubances, hyperexcitability, and heart block = CHLOROQUINE 6) not be given to a patient with a a history of aconnective tissue disorder or a history of granulocytopenia or methemoglobinemia = PRIMAQUINE |
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SELF-INSTRUCTIONAL
Identify the drug used to treat the following: 1) 1st line therapy for P.jiroveci pneumonia 2) treats visceral and cutaneous leishmaniasis 3) recently approved to treat Giardia or Crypto parvum infections 4) treats advanced CNS disease caused by East African trypanosomiasis 5) 1st line teratment of trematode and cestode infections 6) treats toxoplasmosis 7) treats American trypanosomiasis, (aka: Chagas') 8) treats early hemolymphatic stage of Trypanosoma bruci infection 9) alternative drug for treatment of P.jiroveci pneumonia 10) treats enterobius vermicular (pin worm) infection |
1) 1st line therapy for P.jiroveci pneumonia = TMP-SMZ
2) treats visceral and cutaneous leishmaniasis = SODIUM STIBOGLUCONATE 3) recently approved to treat Giardia or Crypto parvum infections = NITAZOXANIDE 4) treats advanced CNS disease caused by East African trypanosomiasis = MELARSOPROL 5) 1st line teratment of trematode and cestode infections = PRAZIQUANTEL 6) treats toxoplasmosis = PYRIMETHAMINE 7) treats American trypanosomiasis, (aka: Chagas') = NIFURTIMOX 8) treats early hemolymphatic stage of Trypanosoma bruci infection = SURAMIN 9) alternative drug for treatment of P.jiroveci pneumonia = PENTAMIDINE 10) treats enterobius vermicular (pin worm) infection = MEBENDAZOLE |
