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18 Cards in this Set
- Front
- Back
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What are the broad classifications of antiplatelet drugs?
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NSAIDS (non-steroidal anti-inflammatory drugs)
Glycoprotein IIb/IIIa receptor inhibitors ADP receptor antagonists Phosphodiesterase 3 inhibitors |
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What are the glycoprotein IIb/IIIa receptor inhibitors?
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Abciximab, tirofiban, eptifibatide
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What are the ADP receptor antagonists?
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clopidogrel and ticlopidine
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What are the inhibitors of phophodiesterase 3?
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Dipyridamole and cilostazol
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Clinical application of aspirin?
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Prevention and treatment of arterial thrombosis
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Pharmacokinetics of aspirin?
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Dose required for antithrombotic
effect is lower than anti-inflammatory dose • duration of activity is longer than pharmacokinetic half-life due to irreversible action |
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What is the mechanism of action of glycoprotein IIb/IIIA inhibitor ABCIXIMAB?
Eptifibatide and tirofiban |
Inhibits platelet aggregation by interfering with GPIIb/IIIa binding to fibrinogen and other ligands
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When is ABCIXIMAB used clinically?
Eptifibatide and tirofiban |
Used during PCI to prevent restenosis
Acute coronary syndrome |
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Route of ABCIXIMAB administration?
Eptifibatide and tirofiban |
Parenteral
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Toxicities of ABCIXIMAB?
Eptifibatide and tirofiban |
Bleeding, thrombocytopenia with prolonged use
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What is the minor difference between ABCIXIMAB and eptifibatide and tirofiban?
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Eptifibatide and tirofiban are a smaller size
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Mechanism of action of clopidogrel?
(Ticlopidine and prasugrel) |
Prodrug: active metabolite irreversibly inhibits platelet ADP receptor
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Uses of clopidogrel?
(Ticlopidine and prasugrel) |
Acute coronary syndrome, prevention of restenosis after PCI, prevention and treatment of arterial thrombosis
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Toxicities of clopidogrel?
(Ticlopidine and prasugrel) |
Bleeding, gastrointestinal disturbances, hematologic abnormalities
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What is a rare side effect of Ticlopidine?
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Older ADP receptor antagonist = higher toxicity
Leukopenia and THROMBOTIC THROMBOCYTOPENIC PURPURA |
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What is the mechanism of action of dipyridamole?
(Cilostazol) |
Inhibits adenosine uptake and inhibits phosphodiesterase enzymes that degrade cyclic nucleotides (cAMP, cGMP)
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When is dipyridamole used clinically?
(Cilostazol) |
Prevention of thromboembolic complications of cardiac valve replacement
--combined with aspirin for secondary prevention of ischemic stroke |
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What are some common side effects of dipyridamole?
(Cilostazol) |
Headache, palpitations, contraindicated in congestive heart failure
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