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28 Cards in this Set
- Front
- Back
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What is the GnRH agonist? |
1. Leuprolide |
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What is the clinical use of GnRH agonists? |
1. Inhibit increase in testosterone synthesis in prostate cancer |
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What are the adverse effects of leuprolide? |
1. Hot flashes 2. Initial flare of cancer ssx 3. Loss of libido and muscle mass 4. Osteoporosis risk |
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What is the androgen receptor blocker? |
1. Flutamide |
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What is the clinical indication of flutamide? |
1. Prostate cancer 2. Usually in conjunction with GnRH agonist
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What are the adverse effects of flutamide? |
1. Gynecomastia |
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What is the GnRH antagonist? |
1. Degarelix |
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What is the indication for degarelix? |
1. Prostate cancer |
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What is the advantage of degarelix over leuprolide? |
1. Degarelix won't cause initial flare-up of ssx 2. Can be extended-release |
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What is the MOA of sipuleucel-T? |
1. Stimulate immune response to PAP 2. Aids in killing of tumor cells that express PAP |
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What are the topoisomerase I inhibitors? |
1. Irenotecan 2. Topotecan |
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What are the topoisomerase II inhibitors? |
1. Doxrubicin |
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For what phase are the topoisomerase inhibitors specific? |
1. S-phase |
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What is the MOA of trastuzumab? |
1. Block HER2--- blocks cancer cell growth |
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With what is trastuzumab often combined to tx cancer? |
1. Polymerization inhibitor |
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What is the MOA of bevacizumab? |
1. Blocks VEGF, thereby inhibiting angiogenesis |
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What drug targets angiogenesis in solid tumors? |
1. Sorafenib tosylate |
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What is the MOA of imatinib? |
1. Inhibits bcr/abl kinase |
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What are the adverse effects of imatinib? |
1. Gi disturbances 2. Neutropenia 3. Thrombocytopenia |
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What is the MOA of erbitux? |
1. Monoclonal antibody that blocks EGF receptor |
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What is the use of interferon a? |
1. Hep B and C 2. Cancer--- enhance host immune response |
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What is the use of IFN B? |
1. MS |
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What is the MOA of IL-2? What is its clinical use? |
1. Promotes T cell growth--- promotes LAK T cell growth 2. Used for metastatic renal cell carcinoma
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What is the use of epoetin alfa? |
1. Promotes erythropoiesis 2. Use in kidney dialysis patients, cancer patients |
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What is filgrastim? What is its use? |
1. G-CSF 2. Used for patients receiving myelosuppressive anti-neoplastic agents |
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What is the clinical use of sargramostim? |
1. Bone marrow transplant patients in recovery 2. Marrow ablation |
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What is the indication for oprelvekin? |
1. Prevents thrombocytopenia |
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What is aldeslukin? |
1. IL-2 |
