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20 Cards in this Set
- Front
- Back
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Cell wall synthesis Inhibitors
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Peptidoglycan ca not found in humans
can inhibit nag nam synthesis or cross linking only affects actively growing cells new thin and weak |
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Penicillins
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Bactericidal
prevent cross linking of peptidoglycan cause cell lysis |
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Natural
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Gram positives
Spirochetes penicillins Cell wall synthesis inhibitors |
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MRSA
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methicillin resistant Staphylococcus aureus
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Synthetic
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more broad spectrum
penicillins cell wall synthesis inhibitors |
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Carbapanems
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Effective on 98 % of hospital isolates
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Monobactams
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Cell wall synthesis inhibitors
penicillins synthetic some gram negatives |
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Cephalosporins
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Cell wall synthesis inhibitors
bactericidal prevent cross linking of peptidoglycan cause cell lysis broad spectrum |
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Bacitracin and Vancomycin
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Polypeptide antibiotics
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Bacitracin
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Cell wall synthesis inhibitor
bactericidal inhibits linear strand synthesis Gram positives topical only |
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Vancomycin
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Cell wall synthesis inhibitor
bactericidal prevent cross linking cause cell lysis gram positives |
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VRE
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Vancomycin resistant Enterococci
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Isoniazid & Ethambutol
bacteriostatic inhibit synthesis of mycolic acid |
Antimycobacterial Antibiotics
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Protein synthesis inhibitors
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Eukaryotes 80s Ribosome Prokaryotes 70 s
Can target 70s but toxic to mitochondria inhibit peptide bond formation attachment of tRNA misreading of mRNA |
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Chloramphenicol
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Protein synthesis inhibitor
bacteriostatic Inhibits peptide bond formation Broad spectrum diffuses easily into tissues, cheap Toxicity- neurotoxic, reduced bone marrow function leads to anemia and leukopenia |
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Aminoglycosides
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Protein Synthesis inhibitors
bactericidal inhibit synthesis, cause misreading of mRNA Gram negatives Toxicity- Auditor nerve damage kidney damage |
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Tetracyclines
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Protein synthesis inhibitor
bacteriostatic inhibit binding of tRNA Broad spectrum including intracell pathogend (Rickettsia, chlamydia, mycoplasma Discolored teeth in children, superinfection of GI, liver damage in pregnant women |
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Macrolides
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Inhibit protein synthesis
bacteriostatic inhibits peptide chain elongation Gram positives |
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Streptogramins
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Protein synthesis inhibitor
bacteriostatic inhibits peptide chain elongation gram positive only Issues- Expensive, high incidence of adverse side effects |
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Oxazolidinones
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Protein synthesis inhibitor
bacteriostatic inhibit ribosomal subunit assembly Gram positives last defense for vancomycin resistant |
