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16 Cards in this Set
- Front
- Back
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First Gen H1 Drugs: Diphenhydramine |
marked sedation, anti motion sickness activity high anticholinergic activity |
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First Gen H1 Drugs: Chlorpheniramine |
slight sedation common component of over the counter cold medicine |
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First Gen H1 Drugs: Promethazine |
Marked sedation antiemetic pre-operative drugs |
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First Gen H1 Drugs: Pyrilamine |
Moderate sedation common in OTC sleep aids |
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First Gen H1 Drugs: Hydroxyzine |
moderate sedation teratogenicity |
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First Gen H1 Drugs: Cyproheptadine |
moderate sedation antiserotonin activity |
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Second Gen H1 drugs have less |
CNS penetration therefore less sedation |
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Second Gen H1 drugs have a longer |
half lives 12-24 hours as opposed to first gen (4-12 hours) |
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Second Gen H1 drugs include |
Loratadine Fexofenadine Desloratadine |
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Second Gen H1 drugs: olopatadine |
Ophthalmic solution that has both H1 antagonism and mast cell stabilizing properties |
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Olopatadine is used clinically |
for the treatment of allergic conjunctivitis |
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Fexofenadine has a lower |
risk of arrhythmia |
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Loratadine and Ceterizine both have |
longer activity (longer half life) |
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Where wakefulness is important- use |
loratadine or fexofenadine |
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H2 receptor Blocker: Cimetidine |
an effecting inhibitor of all phases of gastric secretion - the degree of inhibition is dose dependent -patients relieved of gastric ulcer pain in 3 weeks |
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Cimetidine efficacy is decreased by |
anticholinergics bc they decrease the absorption of said drug Metoclopramide- also decreases the absorption, drug increases intestinal SM movement |
