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4 Cards in this Set
- Front
- Back
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Highly protein bound, aka albumin |
Phenytoin > 90%; valproate 90%; carbamazepine 70-80%; benzos |
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Renally excreted agents |
Gabapentin, pregabalin; carbamazpine, 25% renal |
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Teratogenic |
Vaproate, phenytoin, phenobarbital, carbamazepine |
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Mechanisms of actions |
Gabapentin & pregabalin - voltage gated Ca channel, inhibits glutamate release Phenytoin, valproate, carbamazepine, lamotrigine - decrease Na, Ca influx Phenobarbital, Ca channel; enhance GABA inhibition Benzos, increase frequency of GABA mediated inhibition Barbiturates, increase duration of GABA mediated inhibition |
