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32 Cards in this Set
- Front
- Back
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First line AED agents |
Phenobarbital Phenytoin Carbamazepine Valproic acid |
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Adjunct AED |
Gabapentin |
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AED MOA |
Stabilize nerve cell membrane Limit spread and speed of electrical impulses Raise the seizure threshold Mimic GABA |
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Phenobarbital ADE |
Sedation, dizziness, drowsiness |
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Epilepsy |
CNS disorder Excess electrical impulses in the brain. |
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Partial simple seizure |
No change in consciousness |
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Partial complex seizure |
Some change in consciousness |
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Generalized seizure |
Through out brain- unconscious |
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Status epilepteus seizure |
Seizure continuously until death. |
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Phenobarbital |
Highly addictive Once a day-long half life. Increases the metabolism of other drugs. Can be sleep aid. |
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Phenytoin |
Increases metabolism of other drugs. Most prescribed. |
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Carbamazepine |
Used for generalized or partial seizures. |
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Valproic acid |
Also used for bipolar disorder. |
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AED indication |
Seizure prevention Neuropathic pain Control status epilepticus Trigeminal neuralgia Bipolar disorder. |
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Phenobarbital ADE |
Sedation Therapeutic range: 10-40mcg/ml |
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Phenytoin ADE |
Gingival hyperplasia, dilantin facies, osteoporosis, soft tissue irritation and inflammation at IV site. Therapeutic range 10-20mcg/ml |
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Carbamazepine ADE |
Autoinduction Therapeutic range: 4-12mcg/ml |
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Valproic acid ADE |
Hepatotoxcity/pancreatitis Therapeutic range: 50-100mcg/ml |
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Diazepam ADE |
Hypotension and apnea |
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Selective monoamine oxidise inhibitors |
Selegiline |
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Selegiline. MOA |
Inhibits MAO enzyme from metabolizing dopamine=more dopamine |
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Selective monoamine oxidase inhibiors ADE |
HTN crisis When doses greater than 10mg/day. Tyrannies containing foods |
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Selective monoamine oxidise inhibitors interactions |
Meperidine: serotonin syndrome |
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Dopamine replacement drugs |
Cabidopa-levodopa Can cause malignant melanoma |
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Dopamine replacement drugs MOA |
Exogenous dopamine Restore dopa mine levels Increases "on" time and decrease "off" time |
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Anticholingeric |
Benzotropine |
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Anticholinergic MOA |
Blocks ACh at cholingeric receptors Reduce tremors& rigidity Reverse SLUDGE |
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Anticholinergic contraindicated |
Bladder outlet obstruction |
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Anticholinergic ADE |
Dry mouth, urinary retention, reduced GI motility Anticholinergic syndrome- LOC, blurry vision |
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Anticholinergic interactions |
Antihistamines |
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What diet do you give for dopamine replacement? |
Give with food, juice or low protein snack, fiber and fluids |
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Anticholinergic recommend fluid intake |
3000ml/day |
