Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Mood is related to
|
5ht NE Dopamine
|
|
|
All use monoamine (MA) transmitters and relate to mood... 3 brain systems are
|
Noepinephrine fibers that arise in locus coeruleus in midbrain
Serotonergic fibers originate in areas of raphe - arousal dopaminergic fibers of the mesolimbic system that originate in the ventrak tegmental area |
|
|
History
|
Lithium->MAOI->SSRI
|
|
|
Types of Antidepressants
|
First gen= monoamine oxidase inhibitors MAOIs
tricyclic antidepressants TCAS 2nd Gen: SSRIS NARIS |
|
|
SSRIS first pass metabolism
|
NOT inhibited by alchohol
TCAS are |
|
|
TCAS reach max blood concentrate in...SSRIS?
|
1-3 hrs
4-8 hrs |
|
|
Antideprssants cross
|
BB barrier
Placental Barrier concentrated in lungs kidneys liver brain |
|
|
How do antidepressants work?
|
increase activity in monoamine systmes
MAOIS block monoamine oxidase that breaks down DA, NE, 5-HT SSRIs blok reuptake of 5-HT Tryciclycs prevent reupsorption, anticholinergics Nortiplyine, amoxapinem, venlafaxine are reuptake blockers |
|
|
Excretion
|
MAOIs 2-4 hrs
TCAs 24 hrs SSRIs 15-20 hrs Take long time to feel effect |
|
|
Lithium is main component in mood stabilizers and neurochemiccal mechanisms
|
therapeutic effect: increase 5ht and stabilize membranes
|
