Antidepressants

Front 1

Which are the mood altering diseases that affect the ability to function, lack of energy, sleep disturbances, and loss of libido?

Back 1

Mayor depression and bipolar disorders

Front 2

Intense feeling of sadness

hopelessness

despair

inability to experience pleasure in daily activities

Are manifestations of?

Back 2

Depression

Front 3

Characterized by the opposite behaviour of depression.

Enthusiasm

rapid thought and speech patterns

extreme self confidence

and impaired judgment

Back 3

Mania

Front 4

Drugs that treat mania and depression do so by:

Back 4

potentiating serotonin and / or epinephrine actions

in depression there is not enough quantity of serotonin.

Front 5

Name the 6 SSRI's

Back 5

Fluoxetine (prozac)

Sertraline (zoloft)

Paroxetine (paxil)

Citalopram

Escitalopram

Fluvoxamine

Front 6

This antidepressant type causes less anticholinergic effects and cardiotoxicity

Back 6

SSRI's

Front 7

This SSRI is as effective as TCA for mayor depression without its side effects

Back 7

Fluoxetine (PROZAC)

Front 8

Most widely used antidepressant in the USA

Back 8

Fluoxetine (prozac)

Front 9

This antidepressant is ALSO used for:

obsessive compulsive disorder

bulimia nerviosa

anorexia

panic disorder

premenstrual syndrome

Back 9

Fluoxetine (prozac)

Front 10

available as an enantiomer R and S (s is more stable)

Back 10

Fluoxetine

Front 11

Fluoxetine's side effects

Back 11

Nausea

Sexual dysfunction

Drowsyness

Anxiety

some ppl may be slow metabolizers of this drug

Front 12

If SSRI's are not effective, use this type of drug

Back 12

SNRI's

Front 13

This type of drug is mostly used for neuropathic pain like in diabetic patients.

Back 13

SNRI's

Front 14

Name the SNRI's

Back 14

Venlafaxcine

Duloxetine (Cimbalta)- not used in hepatic disease nor end stage renal disease

Front 15

this type of drug takes 2-12 weeks to show an effective clinical effect

Back 15

SSRI's

Front 16

How do SNRI's work?

Back 16

they inhibit the reuptake of both serotonin and norepinephrine

Front 17

This atypical antidepressant is known to decrease nicotine cravings in tobacco use, so its used to help stop its use.

Back 17

Bupropion

its a weak dopamine and norepinephrine reuptake inhibitor

Front 18

This atypical antidepressant has a slight antidepressant activity

helps pts with imsomnia

increased appetite and weight gain are common

Back 18

Mirtazapine

Front 19

Atypical antidepressants that are both sedatives

Back 19

Nefazodon

Trazodone

Front 20

This type of drug is effective for major depression and for ENEURESIS in children older than 6 y/o

Back 20

Tricyclic antidepressants

TCA

Front 21

This type of drug initial treatment

takes 4-8 weeks, and is

suitable for long term treatment without loss of effectiveness

Back 21

Tricyclic antidepresants

TCA

Front 22

How do Tricyclic antidepressants work?

Back 22

they block norepinephrine and serotonin re-uptake altering selected cns receptors

Front 23

Adverse effects for TCA are:

Back 23

Antimuscarinic:

since it blocks acetylcholine receptors it leads to:

Blurred vision

dry mouth

urinary retention

constipation

agravates glaucoma and epilepsy

Front 24

This type of antidepressant since it increases catecholamine activity it causes bradycardia

which causes orthoestatic hypotention which leads to reflex tachycardia in the elderly

Back 24

TCA

Front 25

This type of antidepressant should be used with caution on manic-depressive patients

and patients taking alpha blockers

and parkinson's disease drugs

Back 25

TCA

Front 26

Why do TCA's have so many side effects?

Back 26

bc they interfere with more than one receptor

they have receptor affinity to muscarinic, histaminergic and adrenergic receptors.

Front 27

This enzyme works as a safety valve to inactivate excess neurotransmitters in the synaptic cleft while at rest

Back 27

MAO

Monoamino Oxidase Inhibitors

Front 28

Pt is unresponsive or allergic to TCA, what drug type should you give him then

Back 28

MAO inhibitors

Front 29

This drug type is used for:

Phobic states

atypical depression

rejection sensitivity

appetite disorders

Back 29

MAO inhibitors

Front 30

How do MAO inhibitors work?

Back 30

they inactivate Monoamino Oxidase within a neuron, causing excess neurotransmitter to diffuse into the synaptic space

Front 31

Name the 2 MAO inhibitors

Back 31

Phenelzine

Tranylcypromide

Front 32

Effects of this type of antidepressant are delayed from 2-4 weeks

has unpredictable effects that limit its widespread use

do not take with tyramine containing foods as this could cause head ache, tachycardia, arrythmias and stroke

Back 32

MAO inhibitors

other side effects include

dry mouth

hypotension

blurred vison

dysuria, constipation

Front 33

Use this drug for prophylactic treatment in manic depressive disorder and manic episodes

Back 33

Lithium Salts

(Eskalith)

Front 34

How do lithium salts work?

Back 34

they act by altering the secondary messenger inositol triphosphate.

Front 35

This type of drug is very toxic with a very low therapeutic index.

slow onset of action

ataxia, tremors, confusion and convulsions

Back 35

Lithium salts

these are used as a last resort

since they are salts they produce excesive stimulation and thats why you get the tremors and the other side effects

Front 36

Name the Tertiary amines (TCA)

Back 36

Imipramine

Trimipramine

Clomipramine

Amitryptiline

Doxepin

Front 37

Name the Secondary Amines (TCA)

Back 37

Desipramine

Nortiptyline

Protriptyline

Maprotiline

Amoxapine