Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
Original drug found to inhibit MAO |
Iproniazid |
|
|
Drug found to inhibit NA/5-HT reuptake |
Imipramine |
|
|
Irreversible MAOA/B inhibitor |
Tranylcypromine |
|
|
Irreversible MAOA inhibitor |
Clorgyline |
|
|
Reversible inhibitor of MAOA (RIMA) |
Moclobemide |
|
|
Side effects of MAOIs |
Increase DA transmission; Increase actions of sympatjomimetic amines, interation with reuptake inhibitors (serotonin syndrome) |
|
|
Major classes of antidepressants |
Monoamine oxidase inhibitors - reversible, irreversible, selective, non-selective; monoamine reuptake inhibitors - selective and non-selective |
|
|
Tricyclic antidepressants (TCAs) |
Amitriptyline |
|
|
Selective serotonin reuptake inhibitor (SSRI) |
paroxetinefluoxetine |
|
|
NA reuptake inhibitor (NARI) |
reboxetine |
|
|
Serotonin and NA reuptake inhibitor |
Venlafaxine |
|
|
Side effects of TCAs |
H1 antagonism - sedation; mACh antagonism - dry mouth; a1 antagonism - postural hypotension |
|
|
What does "serotonin syndrome" cause and why? |
Malignant hypertherma due to a synergistic increase in synaptic 5-HT |
