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14 Cards in this Set
- Front
- Back
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Citalopram and Escitalopram
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Standard SSRI
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Fluoxetine
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Long-term SSRI. Longer half-life than other SSRIs (normally 16-36 hours, 4-5 hours from administration --> peak levels, but 50 hours for fluoxetine, and possibly sustained release). Metabolite of drug also potent. Inhibitor of P450.
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Fluvoxamine
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SSRI. Only indicated for OCD. Mild sedative effect.
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Paroxetine
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SSRI. Inhibitor of P450. Excreted with feces, not via kidneys, as are most SSRIs. Mild sedative effect.
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Sertaline
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SSRI. Only SSRI that undergoes significant first pass metabolism. Excreted through feces.
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Venlafaxine
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SNRI. Potent serotonin reuptake inhibitor at low doses. Norepinephrine reuptake inhibitor at high doses.
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Duloxetine
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SNRI. Inhibits serotonin and norepinephrine reuptake at all doses. Extensively metabolized in the liver.
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Bupropion
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Atypical. Mechanism unknown. Short half life. Reduces nicotine craving.
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Mirtazapine
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Atypical. Antihistaminic and adrenergic-2. Sedating. Can cause weight gain.
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Nefazodone and trazodone
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Atypical. Weak inhibitors of serotonin reuptake. Antihistaminic effect (5-HT1).
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Imipramine
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Prototypical TCA. Often causes orthostatic hypotension.
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Amitriptyline
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TCA. Used for chronic pain.
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Nortriptyline
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TCA. Least likely to cause orthostatic hypotension.
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Phenelzine and tranylcypromine
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MAO inhibitors. Irreversible inactivation of MAO. High incidence of drug-drug and food-drug interactions. Mild amphetamine-like stimulant.
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