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15 Cards in this Set
- Front
- Back
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penecillin
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binds to PBP and inhibits cell wall synthesis (X peptidoglycans)
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cephalosporins
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binds PBP and inhibits cell wall synthess
note: not for Enterococci |
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carbapenems
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high affinity for PBP2, uses OprD porin (littl efflux)
note: enters CSF |
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monobactams
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binds to G- PBP and inhibits cell wall synthesis
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vancomycin
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binds to G+ PBP and inhibits cell wall synthesis
note: good for MRSA note: Red man syndrome |
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macrolides/lincosamides
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bind to 50S ribo, reversibly blocking tRNA binding
well tolerated |
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aminoglycosides
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targets 30S ribo with premature termination and RNA codon misread; causing outer membrane leakage
note: nephrotoxicity, ototoxicity note: used synergistically |
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tetracyclines
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targets 30S ribo preventing aminoacyl tRNA to A site on mRNA
note: photosensitivity, no young kids bc turns teeth brown |
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chloramphenicol
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binds 50S ribo preventing A attachment
gray baby syndrome |
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streptogramins
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attacks 50S ribo
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oxazolinons
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static; binds 50S ribo to inhibit formation of intiation complex
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quinolones
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cidal; bind DNA gyrase (topoisomerase II and IV) blocking DNA synthesis
note: well tolerated, achilles rupture |
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trimethoprim-sulfamethoxazole
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inhibits folic acid synthesis
note: Stevens Johnson Syndrome |
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metronidazole
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cidal; reduced on uptake, release intermediates, free radicals damage DNA
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daptomycin
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cidal; inserts into membrane causing depolarization and K efflux
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