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73 Cards in this Set
- Front
- Back
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rifampin: tx, moa
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TB (used w/ isoniazid), mRNA blocker
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Sulfonamides 1) MOA 2) what other drug has same MOA?
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1. blocks folic acid 2. trimethoprim
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Trimethoprim 1) Main S/E? 2) Ocular S/E of oral tmp? 3) what syndrome can sulfa's cause?
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1. TMP=treats marrow poorly, resulting in aplastic anemia 2. myopic changes 3. Steven Johnson's
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Polytrim contains?
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trimethoprim + polymyxin B
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Amphotericin B 1. moa? 2. what other drugs have same moa?
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1. forms pores (wiffle-ball) in cell wall 2. nystatin, natamycin
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Nystatin's form of intake?
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swish and spit
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natamycin is the drug of choice for what?
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fungal keratitis
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the -azoles' MOA? Main S/E?
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inhibits ergosterol synthesis. liver dysfunction
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griseofulvin moa? uses?
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inhibits cell-wall synthesis. scalp and skin infections
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drugs that inhibit fungal cell walls?
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amp B,nystatin, natamycin, conazoles, griseofulvin
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Bacitracin moa? gram + or -? available in solution or ointment?
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cell wall synthesis. gram +. ointment only.
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Polysporin is made up of? Neosporin?
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Bacitracin and polymyxin B. polysporin + neomycin
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vancomycin moa? tx of choice for what? S/E's?
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cell-wall. MRSA. Redman's syndrome, oto- and nephrotoxic
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Floroqn's moa? 4th generations? 3rd and 4th gen's are more + or -?
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1. DNA gyrase and topoisomerase IV. zymar and vigamox. gram +, while still maitaining -
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1st? 2nd gen?
3rd gen flq's? 4th gen flq's? |
1. nalidixic acid
2. cipro and ofloxacin 3. levo 4. gati and moxi |
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oral Flq's cause what s/e? are topical or oral FLQ's kid-safe?
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oral flqLONES hurt the attachments to your BONES- tendiinitis. topical flq's.
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p-cillins. moa?
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b-lactam ring destroys cell-wall synthesis
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pcn G is given how? pcn V? gram + or -?
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pcn G=booty. pcn V=eat your Veggies. gram + infections.
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augmentin's main s/e?
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diarrhea
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aminopcn's are better than natural pcn's in what way? augmentin is what 2 drugs? aminopcn's main s/e?
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fight gram- infections in addition gram +. clav. acid and amoxicillin (b/c clav. acid protects from penicillianse. hypersensitivity rxns.
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what are the pcnase-resistant pcn's? moa? dicloxacillin is unique how? IV nafcillin tx's what?
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methicillin, nafcillin, dicloxacillin. same as pcn. can be taken orally and used for hordeolums and bleph. orbital cellulitis
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what s/e does methicillin have?
PCN's and what have cross-rxn sensitivity? |
interstitial nephritis. cephalosporin
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Cephalosporins moa? more or less resistant to pcnase? 4th gen's are more + or -?
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same as pcn. more resistant to pcnase than pcn's. 4th gen's are more gram -.
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keflex tx's what?
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dacryoadenitis, dacryocystitis, preseptal cellulitis
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rocephin (ceftriaxone) tx's what?
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meningitis, drug of choice for gonococcal conjunctivitis (given IM)
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c/i's of ceph's?
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pt's with hemophilia b/c they alter Vit k absorption
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what blocks 30S?
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aminoglyc's and tcn's
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what are the aminoglyc's? gram + or -? amiNOglycoside means what?
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genta and tobramycin. broad-spec. N=nephrotoxic O=ototoxic.
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how are aminoglyc's used to tx k ulcers? gentamicin is commonly used for? what is a common s/e of aminoglyc's?
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fortified solutions. septicemia, endocarditis, infected burns and pseudomonas. SPK
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T/F. tcn's are the most broad-spectrum antibiotic. doxycycline commonly tx's what? Minocycline has what major s/e?
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T. meibomitis, acne rosacea, chlamydial eye infections (trachoma and inclusion conj). pseudotumor cerebri.
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tcn's are impaired by what food? S/E's for TCN's?
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dairy. bone growth, photosensitivity, discolored teeth
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what blocks 50S?
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Chloramphenicol, the macrolides (erythromycin, azithromycin, clarithromycin) lincomycin, clindamycin
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bacteriostatic agents? bactericidal agents?
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tcn's and trimethoprim. pcn's, bacitracin, aminoglyc's, ceph's, flq's
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dosage rates of the macrolides?
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azithro-qd charithro- bid erythro- qid
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erythromycin's use? azithromyicn?
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nocturnal lubricant, gonococcal oph. neonatorum. azithro-oral for chlamydia (trach and inc)- topical (azasite) is used for bleph
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clarithromycin's use? s/e's of oral macrolides?
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oral-upper and lower ri's. nausea, diarheaa, ab pain
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linco and clinda's uses? s/e's?
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mrsa. pseudomembranous colitis
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metronidazole's moa? use?
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inhibits nucleic acid synthesis. rosacea
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RIPE for TB drugs stands for? rifampin's ocular s/e? isoniazid tx's what? isoniazid's ocular s/e? ethambutol causes what?
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rifampin, isoniazid, ethambutol. pink tears! latent tb. optic neuritis. bilateral, retrobulbar ON.
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what is rifabutin?
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a new rifampin derivative that causes uveitis
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sulfa's and trimethoprim tx + or -?
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broad spec
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oral sulfamethozole in combo w/ tmp tx what?
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UTI's
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what is used to tx toxoplasmosis?
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sulfadiazine in combo w/ pyrimethamine
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what drug shares the same moa as tmp?
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pyrimethamine
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tmp tx's what? does it tx pseudomonas?
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broad-spec. no
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oral sulfa's, tmp and pyrimethamine cause what?
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GI effects
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oral sulfa's cause what? r they safe in pregnancy?
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nephrotoxic, kernicterus, myopia. No
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what else besides topical and oral sulfa's cause SJS?
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oral CAI's
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main s/e of amp B?
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nephrotoxic
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is natamycin safe in pregnancy?
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caution-C
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which conazole can be used as sunconj injection?
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flu-
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besides MRSA, what does vanco tx?
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baterial endophthalmitis
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MRSA is resistant to what else besides methicillin?
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ceph's, aminog's, macrolides
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FLQ's tx what?
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anything bacterial- ulcers, bact. conj., gonorrhea, etc.
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cipro's spectrum? cipro tx's what?
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broad. UTI's and GI infections
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Avelox is what gen. FLQ? Known as what?
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4th. "respiratory quinolone" (tx's bronchitis, pneumonia, etc.)
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which topical FLQ is the only one not approved for 1 yr and up?
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Quixin
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natural pcn's tx what?
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strep, syphilis, meningitis, pneumococcal infections
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how good is oral absorption of pcn's? impaired by what?
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poor. impaired by any food (take 30 min or 2 h after meals)
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what are the aminopcn's? which is absorbed better orally?
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ampi and amoxi. amoxi.
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aminopcn's tx what?
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otitis media and resp. infections in kids- which are caused by Haemoph. infl.
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what 2 bacteria do methi, nafci and dicloxacillin target?
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s. aureus and staph epi. (b/c these produce pcnase)
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what can pcn's render ineffective?
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oral ccp's
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what is the tx of choice for gonococcal conj? type of drug?
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Rocephin. Ceph.
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tobramycin is available in what form?
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topical and ointment.
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PAT an empty stomach stands for?
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pcn's, azithromycin, tcn's
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tcn's are commonly rx'd for?
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acne, chlamydia, mycoplasma pneumonia, Lyme dz
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which of the tcn's is safe in renal failure pts?
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doxy
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which of the tcn's is safe in renal failure pts?
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doxy
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chloramphenicol: + or -?. formulations?
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broad-spec. ointment, drop, oral
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s/e's of chloramphenicol?
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aplastic anemia, optic neuritis, grey baby syndrome
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oral erythro tx's what?
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chlamydia
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isoniazid can be used how for latent TB?
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in isolation
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