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15 Cards in this Set
- Front
- Back
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Aminoglycosides dosing?
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IBW
- used primarily for aerobic gram (-) bacilli - concentration dependent bactericidal activity |
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What are the major uses of Amikacin, gentamicin, tobramycin?
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HAP
VAP Meningitis Intra-abdominal infections Synergy w/ B-lactam and vancomycin --> psuedomonas. |
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What are the major uses of Streptomycin?
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TB
MAC (mycobacterium avium complex) |
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What are the major uses of Neomycin?
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- Topical for minor skin infections.
- Oral for pre-operative abdominal antisepsis. |
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What are the major uses of Kanamycin?
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intra-abdominal infections.
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What are reNal dosing?
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- dosing adjustment necessary except NEOMYCIN
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What are hepatic dosing?
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- gentamicin and tobramycin.
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Neomycin --> do not use:
Nephrotoxicity: Ototoxicity: |
if intestinal obstruction
reversible -- monitor levels. irreversible -- damage to vestibular or cochlear structures (both) NEUROMUSCULAR BLOCKADE AND NEUROTOXICITY. |
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Increase Nephrotoxicity:
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- PCN, cephalosporins, amphotericin B, loop diuretics, vancomycin.
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Increase Ototoxicity:
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- Vancomycin, loop diuretics.
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When compared with aminoglycosides what might decrease the efficacy of the drug?
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PCN Antibiotics.
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What are the drugs that are related to aminoglycosides?
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Kanamycin
Amikacin Gentamicin Neomycin Streptomycin Tobramycin |
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Lincoamides
1. cross resistance: 2. Cross allergenicity: |
1. macrolides, ketolides, streptogramins, lincoamides.
2. macrolides, ketolides, streptogramins. |
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Renal impairment:
Hepatic impairment: |
reduce dose of lincomycin.
dose adjust for both. |
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Lincosamides:
MAY enhance the neuromuscular - blocking effect of the neuromuscular - blocking agents. |
- anaerobic (bacteriodes, peptococcus, peptostreptococcus, protozoa.)
- staph and strept. |
