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15 Cards in this Set

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Aminoglycosides dosing?
IBW
- used primarily for aerobic gram (-) bacilli
- concentration dependent bactericidal activity
What are the major uses of Amikacin, gentamicin, tobramycin?
HAP
VAP
Meningitis
Intra-abdominal infections

Synergy w/ B-lactam and vancomycin --> psuedomonas.
What are the major uses of Streptomycin?
TB
MAC (mycobacterium avium complex)
What are the major uses of Neomycin?
- Topical for minor skin infections.
- Oral for pre-operative abdominal antisepsis.
What are the major uses of Kanamycin?
intra-abdominal infections.
What are reNal dosing?
- dosing adjustment necessary except NEOMYCIN
What are hepatic dosing?
- gentamicin and tobramycin.
Neomycin --> do not use:
Nephrotoxicity:
Ototoxicity:
if intestinal obstruction
reversible -- monitor levels.
irreversible -- damage to vestibular or cochlear structures (both)
NEUROMUSCULAR BLOCKADE AND NEUROTOXICITY.
Increase Nephrotoxicity:
- PCN, cephalosporins, amphotericin B, loop diuretics, vancomycin.
Increase Ototoxicity:
- Vancomycin, loop diuretics.
When compared with aminoglycosides what might decrease the efficacy of the drug?
PCN Antibiotics.
What are the drugs that are related to aminoglycosides?
Kanamycin
Amikacin
Gentamicin
Neomycin
Streptomycin
Tobramycin
Lincoamides
1. cross resistance:
2. Cross allergenicity:
1. macrolides, ketolides, streptogramins, lincoamides.
2. macrolides, ketolides, streptogramins.
Renal impairment:

Hepatic impairment:
reduce dose of lincomycin.

dose adjust for both.
Lincosamides:

MAY enhance the neuromuscular - blocking effect of the neuromuscular - blocking agents.
- anaerobic (bacteriodes, peptococcus, peptostreptococcus, protozoa.)
- staph and strept.