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22 Cards in this Set
- Front
- Back
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Penicillins
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Bind PBPs
Bactericidal Targets Gm + Inhibited by Beta-lactamases; efflux of drug, porin size (Gm -) |
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Methicllin
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Bind PBPs
Bactericidal Targst Gm+ Inhibitions: see penicillin Resistant to inactivation by penicillinase of CA-MRSA |
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Ampicillin
Amoxicillin |
Bind PBPs
Bactericidal Targets Gm + and growing E. coli Inhibitions: See Penicillin |
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Carbenicillin
Ticaricillin |
Bind PBPd
Bactericidal Targets Gm +, Gm -, including Pseudomonas |
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Cehpalosporins
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Bind PBPs
Bactericidal Target depends on generation Inhibitions: see Penicillin |
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Monobactams
(Aztreonam) |
Bind PBPs
Bactericidal Taregts Aerobic Gm - Resistant to Beta-lactamases given to those allergic to penicillin |
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Vancomycin
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Affect (d-ala)2 chain in growing cells
Bactericidal Targets MRSA; C. difficile Inhibitions: doesnt cross OM of Gm- Drug of last resort |
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Isoniazid
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Affects Mycolic acid synthesis
Bactericidal targets growing Mycobacteria Inhibitions: decresed drug uptake; resistance in TB |
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Aminoglycosides
Streptomycin Gentamycin Kanamycin |
Irrev. bind of 30S ribo
Bactericidal Gm - incl Pseudomonas Ineffective vs anaerobes, streptococci, enterococci Inhibitons: mutation in 30S binding site |
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Lincosamides
Clindamycin |
Bind 50S ribo subunit
Bacteriostatic Targets: Strep, Staph, gm- robs; anarobes except for C. difficile Inhibitons: plasmid encoded resistance |
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Tetracyclines
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Revers. binding of 30S ribo. subunit
Bacteriostatic Targets: Selective Gm - and +; chlamydia, Rickettsia, Mycoplasma Inhibitions: active efflux Stain teeth in kids |
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Macrolides
Erythromycin Azithromycin |
Rev. bind 50S ribo
Bacteriostatic Targets: Mycoplasma, Chlamydia Ineffective vs Enterobacteriaceae Inhibitons: 23S rRNA gets methylated |
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Rifampin
Rifamycin B Rifabutin |
Binds RNA pol
Bactericidal vs TB Bacteriostatic vs Staph & strep Targets TB; Neisseria meningitidis prophylaxis; M. avium Inhibitons: Gm+: altered beta subunits Gm-: decreased drug uptake Turns urine orange |
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Chloramphenicol
(Cm or Cam) |
Revers. binds 50S ribo; prevents peptide bond formation
Bacteriostatic Targets salmonella typhi Inhibitons: Cm acetyltransferase; alter OM porins |
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Sulfonamides
(SFX) |
PABA antagonists; inhibits dihydropteroate synthetase
Bacteriostatic Targets a broad spectrum Inhibitions: plasmid encoded resistance |
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Trimethoprim
(TMP) |
Dihydrofolate reductase inhibitor
Bacteriostatic Targets a broad spectrum Inhibitons: plasmid encoded resistance |
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Fluoroquinolones
Ciprofloxacin Levofloxacin |
Inhibit alpha subunit of DNA gyrase
Bactericidal Targets a borad spectrum Inhibitons: altered alpha subunit |
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Polymixin B
Polymixin E (colistin) |
Interact with LPS, phospholipids in OM
Bactericidal Targets Gm-; Pseudomonas Inhibitons: Gm + lack OM |
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Bacitracin
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Inhibits lipid carrier of peptidoglycan
Bactericidal Targets Gm+ Inhibiions: Gm -; intrinsic resistance Topical use only |
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Pleuromutilins
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Interact at 50S ribo subunit in PTC at A and P sites
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Daptomycin (Cubicin)
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IV, used vs Gm + cocci
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Tygercycline
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Potent vs tet-R bacteria (MRSA, VRE)
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