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12 Cards in this Set
- Front
- Back
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Amantadine (Influenza)
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- M2 ion channel blocker
- Targets the virus at the uncoating stage - Only effective against type A - Administered orally - Given in > 1 year old - Up to 30 % of resistance |
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Zanamivir (Influenza)
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- Neuraminidase inhibitors
- Targets the release stage - Effective against type A and B - Administered by inhalation - Given in > 7 years old children - Not given in pregnancy - Virtually no resistance |
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Oseltamivir (Influenza)
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- Neuraminidase inhibitors
- Targets the release stage - Effective against type A and B - Administered orally - Can be given at any age - Unfrequent but present resistance - Decreases the duration of the ilness |
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Population to treat with influenza antivirals
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- Illness requiring hospitalization
- Progressive to severe complicated illness - Risk for severe disease - Essential healthcare workers - Patients with chronic medical conditions - Patients in nursing homes - Patients > 65 years old - Pregnant women - Healthy children of < 24 months - Severe obese |
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Acyclovir (Herpes)
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- Guanosine analog
- Active against : Herpes simplex virus (HSV) (higher affinity) and Varicella zoster virus (VZV) (lower activity) - Inhibits DNA synthesis - Given PO for : Genital herpes, oro-labial herpes and primary VZV - Given IV for : HSV encephalitis, Neonatal HSV, Immunocompromised patients - Given in topical form for : Keratoconjunctivitis |
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Valacyclovir (Herpes)
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- Pro-drug of acyclovir
- Only PO |
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Penciclovir/Famcyclovir (Herpes)
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- Famcyclovir is the prodrug of Pencyclovir
- Same mechanism of action as acyclovir - Used for : Genital herpes, oro-labial HSV, primary VZV or VZV zoster |
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Gancyclovir (Cytomegalovirus)
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- Used for patients suffering from : CMV retinitis, CMV pneumonitis and Congenital CMV
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Valgancyclovir (Cytomegalovirus)
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- Prodrug of gancyclovir
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Interferon-α (Hepatitis B virus and Hepatitis C virus)
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- No direct antiviral action
- Acts via host cells activation - Given by injection - Given in patients suffering from : Chronic HBV and acute or chronic HCV |
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Ribavirin (Chronic HCV)
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- Provoques phosphorylation by host cells
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Nucleoside/nucleotide inhibition (Chronic HBV)
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- Given orally
- Works by phophorylation |
