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29 Cards in this Set
- Front
- Back
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Obligate Intracellular Parasite
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Virus
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Preferred approach to treat Influenza A
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immunization
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Why use an antiviral for a resp. disease?
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If pt is allergic to vaccine or if the outbreak is due to an immunilogical variant
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Oseltamivir (tamiflu)
Zanamivir (relenza) |
Neuraminidase inhibitors
inhibit release of new virions and their spread from cell to cell |
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Drugs that are effective against Influenza A & B
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Oseltamivir (Tamiflu)
Zanamivir (relenza) |
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Amantadine (symmetrel)
Rimantadine (flumadine) |
Inhibitors of viral uncoding
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Drugs that are only effective against Influenza A
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Amantadine (symmetrel)
Rimantadine (flumadine) |
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Most common causes of chronic hepatitis
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Hep B and C
Current therapy is available |
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Acute Hepatitis
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Hep A
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Tx Chronic Hep B
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Interferon- Alpha
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Tx of Hep C
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Combo of interferon-alpha and ribavirin
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Interferes with the ability of virus to infect cells
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Interferon
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When are herpes drugs effective
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only in the acute phase of the viral infection
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Acyclovir (Zovirax)
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Treats HSV 1, 3 and varicella zoster
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TOC for HSV encephalitis
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Acyclovir (Zovirax)
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Most common use for Acyclovir
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genital herpes infections
therapy and prophylaxsis |
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Valacyclovir
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Greater oral availability
Rapidly hydrolyzed to acyclovir Achieves comparible levels |
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Treatment of CMV induced retinitis in a pt with AIDS
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Cidofovir (vistide)
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Treatment for CMV retinitis for acyclovir-resistant HSV and herpes zoster
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Foscarnet (foxcavir)
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Analog of acyclovir that has 20x greater activity against CMV
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Ganciclovir (Cytovene)
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HAART
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highly active anti-retroviral therapy
Multi drug regimine for AIDS |
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Current reccomendation for primary aids therapy
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2 NRTIs with either a PI or NNRTI
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Side effect of NRTIs
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potentially fatal liver toxicity
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Decreases viral load
Increases CD4+ count |
Zidovudine (AZT)
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Advantages of NNRTIs to treat AIDS
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Lack of effect on the host blood-forming elements
lack of cross-resistance with NRTIs |
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Problem with NNRTIs
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high rate of hypersensitivity reactions
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Nevirapine
Delavirdine |
NRTIs
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When are protease inhibitors used?
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treatment of anti-retrovirally naive patients
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Results of PI + 2 NRTIs
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decrease in plasma viral load to undetectable levels
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