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9 Cards in this Set
- Front
- Back
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antibiotics
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amphotericin B - binds to ergosterol...puts holes in membrane
for lumen of GI fungus - ORAL version TI - narrow K+ supplements, due to renal wasting of K and Mg DONT USE in anemia, renal diease, hypokal, hypo mag can cause thomboplebitis C. lusitaniae and P. boydii - innately resistance to amp B |
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antimetabolites
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flucytosine- blocks DNA syn
use with deep candida infections, CRYPTOCOCCAL mengistis with AmP B Chromoblastomycosis (with Itraconazole) |
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azoles
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ketoconazole/fluconazole
blocks ergosterol synthesis can become resistant by changing sterol gene - inhib andro + cortiosteroids - potentiates other drugs (warafin) FLUCONAZOLE - good in CNS Adverse - gynecomast, libido, impotence Seborrheic dermatisis - Ketoconazole Contra - no prego |
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systemic drugs
(superfical infections) |
griseofulvin - disrupts mitotic spindle, Fungistatic
works against DERMATOPHYTES HAIR, NAILS, SKIN (KERATIN) can induce Cp450 |
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systemic drugs
(superfical infections) |
terbinafine - blocks syn of ergo
hair nail skin inhibits squalene epoxidase |
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topical antifung
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nystatin - local candidiasis in OBESE PTs, where skin rubs
vaginal, oral, cutaneous |
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topical antifung
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tolnaftate - tinea pedis (not against canddia)
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antifung azoles topical
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dermatophyte infections
TENIA versicolor |
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echinocandids
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capsofungin, micafungin (prophylaxis for BMT), anuidugafungin
fungal cell walls... Aspergillus & Candida -resistance with FSK1 mutation caution in hepatic insuff |
