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5 Cards in this Set
- Front
- Back
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Classifications ABCD SHIP |
Aliphatic carboxylic acid Barbiturates Benzodiazepines Carboxylic acid derivatives Deoxybarbiturates Succinamide Hydation Iminostilbenes Phenylthirazine newer drugs |
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Moa |
#Na+channels blocked at its inactivated state #ca2+channel blockers- attenuation of T current which is mediated by ca2+ #enhasment of response to GABA #GABA transamminase inhibitors |
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Adverse effects |
Phenytoin- fetal hydantation syndrome,hirsutism,gingival hyperplasia,gum hypertrophy,osteomalacia Carbazepine- autoinduction of metoblisim,granulocyte suppression, aplastic anemia, teratogenicity, exacerbates abscence seizure,ADH action enhacement. Valproic acid- PCOD,menustral cycle irregularities, teratogenicity-spina bifida, tremor ,hair loss,abdominal pain,heartburn. |
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Uses |
Phenytoin-epilepsy Cbz- trigeminal $ glossopharangeal neuralgia, mood stabilizer in bipolar disorder Valproic acid- epilepsy |
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Newer drugs |
Gabapentine Pregabalin Tiagabine Zonisamide Lacosamide topiramate |
