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32 Cards in this Set
- Front
- Back
- 3rd side (hint)
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S-Phase Specific Anti Cancer Drugs
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Cytarabine
6-Mercaptopurine 6-Thio Guanine 5-Fluro Uracil Methotrexate HydroxyUrea Irinotecan Etoposide |
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G2 Phase Specific Anti Cancer Drugs
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Bleomycin
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M Phase Specific Anti Cancer Drugs
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Vincristine
Vinblastine Paclitaxel |
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G0 Phase Specific Anti Cancer Drugs
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Alkylating Agents
Anti Tumor Antibiotics Nitrosoureas Cisplatin |
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Cyclophosphamide
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Damages DNA Guanine N7
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SE: BMS, Hemorrhagic cystitis
(Acrolein formed from CP causes Hemorrhagic cystitis and bladder fibrosis. Rx Antidote-Mesna |
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Cisplatin
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Cross-links DNA strands
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SE: Nephrotoxicity-Use: Amifostine
Worst Nausea-Use: Ondensetron |
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Procarbazine
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Alkylating agent
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Anti-cancer drug causing cancer
BMS |
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Doxorubicin
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Forms Free radicals and inhibits Topoisomerase
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SE: BMS
Delayed CHF- Use: Dexrazoxane-Prevents free radicals injury to heart |
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Methotrexate
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Inhibits DHF Reductase
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SE: BMS-Use: leucovorin
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5-Flurouracil
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Pyrimidine Anti-metabolite
Inhibits thymidylate synthetase dUMP to dTMP inhibition Thymineless death |
SE: BMS
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6-Mercaptopurine
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Purine Anti metabolite bioactivated by HGPR Transferase
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SE:BMS
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Bleomycin
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Complexes with Fe and O2
DNA Strand scissor |
SE: Pneumonitis
Pulmonary Fibrosis |
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Vinblastin, Vincristine
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decreases microtubular polymerization
SPINDLE POISON |
SE of Vinblastin: BMS
SE of Vincristine: Neurotoxicity, Peripheral Neuropathy and peripheral tingling sensation |
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Irinotecan
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Blocks Topoisomerase-I
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SE:
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Etoposide
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Blocks Topoisomerase-II
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SE:
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Renal Toxicity
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Cisplatin Use: Amifostine
Methotreaxate |
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Pulmonary Toxicity( Pulmonary Fibrosis)
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Bleomycin
Busulfan Procarbazine (Amiodarone) |
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Cardiac Toxicity
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Doxorubicin
Daunorubicin |
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Neurotoxicity
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Vincristine
Cisplatin |
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Immunosupression
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Cyclophosphamide
Methotrexate |
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Bladder Toxicity
Hemorrhagic cystitis |
Cyclophosphamide Use-Mesna
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Pancreatitis
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Asparaginase
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Interleukin-2 (Aldes Leukin)
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Increases Lymphocytes differentiation and NKs
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Used in Renal cell cancer and metastatic melanoma
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IL-11
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Increases Platelet formation
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Used in thrombocytopenia
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Filgrastim G-CSF
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Increases Granulocytes
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Used for Marrow recovery
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Sargramostim GM-CSF
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Increases Granulocytes and Macrophages
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Used in marrow Recovery
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Erythropoietin
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Anemias of renal failure
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Thrombopoietin
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Thrombocytopenia
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Paclitaxel
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Blocks Depolymerization of microtubules
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Alkylating agents
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Cyclophosphamide
Cisplatin Procarbazine |
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Anti- Tumor Anti biotics
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Doxorubicin
Daunorubicin |
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Nitrosoureas
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Lomustine
Carmustine |
Very effective for brain cancers
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