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10 Cards in this Set
- Front
- Back
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Charcteristics of cell cycle specific drugs
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Don't act in G0 phase, used in a schedule dependent way, best killing is seen if drug is given in repeated small fractions, work best of tumors with high GF
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Which drugs are CCS?
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Antimetabolites, Vinka alkaloids, padaphyllotoxins (G2/s), Bleomycin (G2)
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Characteristics of CCNS drugs?
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cytotoxic effect at any time in cell cycle, dose dependent effect
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Which drugs are CCNS?
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alkylating agents, platinums, DNA breakers, antibiotics (except bleomycin)
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Log-kill hypothesis
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cancer drugs kill a fixed proportion of the cancer cells not a fixed number
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4 classes of anti cancer drugs
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DNA alkylatinf agents, antimetabolites, drugs that act on mitotic spindle, antibioticsm hormonal agents
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this class of drugs does concentration dependent killing
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CCNS
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what is growth fraction/
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proportion of tumor cells that are actively dividing
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vinca alkaloids act in what phase?
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M phase
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Podophyllotoxins act in what phase?
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early G2 or s phase
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